Abstract：Objective：To establish a model of cervical cancer in SCID mice,explore the inhibition effect of TSA on growth of grafted tumor,and the expression of TR3. Methods:Caski cells were inoculated hypodermically into the forelimbs of 20 SCID mice. After 1week,TSA was injected into the abdominal cavity of 20 SCID mice,which were randomized into 4 groups(group A 2mg/kgTSA, group B 1mg/kgTSA, group C 0.5mg/kgTSA, control group 0 mg/kgTSA).32 days later,observe the growth of xenografts tumor in SCID mice in each group,the inhibitiong rate was calculated. Immunohistochemistry was used to detect the expression of TR3 protein in each group tumor. Results:Tumor growth curve of each treatment group,weight and volume,compared with the control group was significantly inhibited（p<0.05）.The expression of TR3 protein in group A showed strong positive, positive in group B,and a weak positive in group C. The TR3 expression in control group was negative.Conclusion: The tumor growth in mice is inhibited by TSA,and TSA affect TR3 expression in mice transplanted tumor cells.
李新春,周彦杰,周奕,曹味纯. 曲古菌素A影响SCID鼠人宫颈癌移植瘤生长的研究[J]. 实用预防医学, 2015, 22(6): 689-692.
LI Xin-chun, ZHOU Yan-jie, ZHOU Yi, CAO Wei-chun. Inhibitory effect of TSA on growth of grafted human cervical carcinoma in SCID mice. , 2015, 22(6): 689-692.
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2015, Vol. 22 
