内蒙古蒙、汉族女性相关因素与阿尔茨海默病关系的以社区为基础的病例-对照研究

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摘要目的通过对内蒙古牧区55岁以上蒙、汉族女性人群月经、生育状况及相关因素以流行病学为基础的研究,探讨其与阿尔茨海默病关系。方法以阿尔茨海默病（Alzheimer's disease, AD）的流行病学现患状况调查为基础,对女性月经、生育水平与AD的关系进行相关性研究。结果蒙古族老年女性AD组平均生育次数显著高于对照组t=4.044,P=0.000）,初潮年龄、绝经年龄比较差异无统计学意义（P>0.05）;汉族老年女性AD组与对照组相比绝经年龄及平均生育次数差异有统计学意义（t=1.979,P=0.048;t=-8.214,P=0.000）,初潮年龄差异无统计学意义（t=-1.139,P=0.255）,使用非条件Logistic逐步回归进行多因素分析,结果发现在蒙古族55岁以上人群中年龄、教育水平、糖尿病史、冠心病史与AD有显著性联系,其中年龄、糖尿病、冠心病是AD的危险因素,受教育程度是AD的保护因素OR值为0.202。在汉族55岁以上人群中年龄、教育水平、冠心病史,生育次数与AD有显著性联系。其中年龄生育次数是AD的危险因素（OR=1.148）,受教育程度是AD的保护因素（OR=0.221）。结论生育多胎可能是蒙古族55岁以上女性人群患AD的危险因素;生育多胎及绝经年龄较早可能是汉族55岁以上女性人群患AD的危险因素,多种因素对于AD发病可能存在交互作用。

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	呼日勒特木尔
	张国华
	贺娟
	王智光
	江名芳
	张春雨

关键词 ：雌激素水平, 阿尔茨海默病, 危险因素, 蒙古族

Abstract：Objective To study the Alzheimer's disease (AD) of female who≥55 years old of menstruation, reproductive status and related factors on the basis of epidemiological of Mongolian and Han population in Inner Mongolia pasturing area. Methods On the basis of the epidemiology of survey to female menstruation, fertility and the correlation studies in AD.Results The Mongolian older women AD group compared with control group in average number difference was statistically significant（t=4.044,P=0.000）.Comparing the menarche age, menopausal age ,there was no statistically significance between them（P>0.05）.Han older women AD group compared with control group menopausal age, and the fertility rate difference was statistically significant（t=1.979,P=0.048;t=-8.214,P=0.000）.There was no statistically significant difference of menarche age（t=-1.139,P=0.255）.Use the unconditioned Logistic stepwise regression analysis of many factors, Found in the Mongolian people who≥55 years old, education level, diabetes history, history of coronary heart disease have significant connection with the AD, age、diabetes and coronary heart disease are risk factor for AD（OR=1.695~5.200）. Level of education is the protection factor for AD（OR=0.221）.Conclusion Multiple births may be the risk factor for Mongolian women who≥55 years old ;Multiple births and the earlier age of menopause may be AD risk factors for han female population aged over 55. Various factors may interact with each other for AD.

Key words： Estrogen level Alzheimer's disease Risk factors Mongolian

基金资助:内蒙古自治区科技厅应用技术研究与开发资金资助,编号：2010MS1121; 2内蒙古教育厅青年科技领军人才项目资助; 3内蒙古自治区科技计划项目,编号：KJT10JHN

通讯作者: 张春雨,Email:chunyu1994@163.com

引用本文:

呼日勒特木尔,张国华,贺娟,王智光,江名芳,张春雨. 内蒙古蒙、汉族女性相关因素与阿尔茨海默病关系的以社区为基础的病例-对照研究[J]. 实用预防医学, 2015, 22(6): 655-658. HU Riletemuer, ZHANG Guo-hua, HE-Juan, WANG Zhi-guang, JIANG Ming-fang, ZHANG Chun-yu. Epidemiology based case - control study of relationship between Alzheimer’s disease and menstruation, fertility status and related factors of Mongolian and Han female population living in Inner Mongolia pastoral area. , 2015, 22(6): 655-658.

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https://www.syyfyx.com/CN/ 或 https://www.syyfyx.com/CN/Y2015/V22/I6/655

[1] Vest RS, Pike CJ.Gender, sex steroid hormones, and Alzheimer's disease. Horm Behav. 2013 ,63(2):301-7
[2] Burkman R T, Collins J A, Greene R A. Current perspectives on benefits and risks of hormone replacement therapy. American J Obstetrics and Gynecology, 2001, 185(2): 13-22
[3] Yaffe K. Hormone therapy and the brain-deja vu all over again? JAMA. 2003;289:2717-2719
[4] Eberling JL,Reed BR,Coleman JE,et a1．Effect of estrogen on cerebral glucose metabolism in postmenopausal women I-J]．Neurology,2000,55：875-877．
[5] Villarroya．Pastor MT．Profile of Alzheimer’S disease in women[J]．Rev Neurol,2001,32(12)：1178-1181．
[6] Gao S,Hendrie HC,Hall KS,et a1．The relationships between age,sex,and the incidence of dementia and Alzheimer disease：a meta·analysis [J]．Arch Gen Psychiatry,1998,55(9)：809-815．
[7] American Psychiatric Association.Diagnostic and statistical manual of mental disorders. 4th (DSM-IV).Washington: American Psychiatric Association, 1994.143-147.
[8] McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease.Neurology, 1984,34, 939-944.
[9] 呼日勒特木尔,张春雨,赵世刚,等。内蒙古牧区蒙、汉族Alzheimer病患病率的研究。临床神经病学,2013,26（1）：1-4.
[10] Liu L,Guo X,Zhou Y.Prevalence of Dementia in China[J].Dement Geriatr Cogn Disord.2003;15:226-230.
[11] Qiu J.Ticking time bomb faced by China's ageing population[J].Lancet
Neurology.2007;6:582-583.
[12] Chandra V,Pandav R, Dodge HH, et a1． Incidence of A lzheimer’s disease in a rural community in India：the Indo-USstudy [J]．Neurology,2001,25：57(6)：985-989．
[13] Hendrie Hc,Ogunniyi A,Hall KS,et a1．Incidence of dementia and Alzheimer disease in 2 com munities：Yoruba residing in Ibadan,Nigeria,and African Am ericans residing in Indianapolis,Indiana [J]．JAMA,2001,285(6)：739-747
[14] Zhang ZX, Zahner GE, Román GC, Liu XH, Wu CB, Hong Z, Hong X, Tang MN, Zhou B, Qu QM, Zhang XJ, Li H．Socio-demographic variation of dementia subtypes in China：methodology an d results of prevalence study in Beijing,Chengdu,Shanghai,and Xi’an[J].Neumepidemiology．2006;27(4):177-187．
[15] Candore G, Balistreri CR, Grimaldi MP, Vasto S, Listì F, Chiappelli M, Licastro F, Lio D, Caruso C. Age-related inflammatory diseases: role of genetics and gender in the pathophysiology of Alzheimer’s disease [J]. Ann N Y Acad Sci. 2006;1089: 472-486.
[16] Zhang X, Zhou K, Wang R, et al. Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation[J]. J Biol Chem.2007;282 ( 15 ) : 10873-10880.
[17] Sundermann E, Gilbert PE,Murphy C. Estrogen and performance in
recognition memory for olfactory and visual stimuli in females diagnosed with Alzheimer’s disease [ J ]. Int Neurop sychol Soc.2006;12(3) : 400-404.
[18] Seshadri S, Zornberg GL, Derby LE, et al. Postmenopausal estrogen replacement therapy and the risk of Alzheimer disease[J]. Arch Neurol. 2001;58:435-440.
[19] Mulnard RA,Cotman CW ,Kawas c,et a1．Estrogen replacement therapy for treatment of mild to moderate Alzheim er’S disease．A random ized controlled tria1．Alzheimer’s disease Cooperative Study [J]．JAMA,2000,2836：1007．1015．
[20] Henderson VW.Alzheimer's disease: Review of hormone therapy trials and implications for treatment and prevention after menopause. J Steroid Biochem Mol Biol. 2013,28.
[21] Morris JC.Dementia update 2005[J]. Alzheimer Dis Assoc Disord.2005;19:100-117.
[22] Shumaker SA,Legault C,Rapp SR et al. Estrogen plus progestin and incidence if dementia and mild cognitive impairment in postmenopausal women.The women’s health initiative memory study:a randomized controlled trial.JAMA,2003,289:2651-2662.
[23] Thal L J,Thomas R G,et al.Estrogen levels do not correlate with improvement in cognition[J].Archives of Neurology,2003,60(2):209-212.