Abstract：Objective To evaluate the correlation of mtDNA4977 and presbyacusis using meta-analysis. Methods Databases including PubMed,Embase,CBM,CNKI,WanFang Data,WanFang Med and VIP were searched to collect case-control study on the correlation of mtDNA4977 and presbyacusis,according to the inclusion criteria,collecting the research findings of related articles and conducting a statistic analysis. Results A total of six studies were included in the meta-analysis. The results of meta-analysis showed that the persons with mtDNA4977 deletion had an increased risk of presbyacusis (OR=7.19,95%CI:2.90~17.85) and the difference was statistically significant (P<0.0001). Conclusions MtDNA4977 deletion is related to presbyacusis.
王致, 荣幸, 邹文英, 陶志民, 梁嘉斌, 刘移民. mtDNA4977缺失与老年性聋关系的Meta分析[J]. 实用预防医学, 2016, 23(3): 264-266.
WANG Zhi, RONG Xing, ZOU Wen-ying, Tao Zhi-min, LIANG Jia-bin, LIU Yi-min. Correlation of mitochondrial DNA 4977 bp deletion and presbyacusis: a meta-analysis. , 2016, 23(3): 264-266.
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2016, Vol. 23 
