Effects of grape seed proanthocyandin extract on pulmonary ventilation and inflammationin elderly patients with obstructive sleep apnea-hypopnea syndrome
LI Li-qun, HAO Zheng-wei, GE Yan-lei,ZHAO Ya-ning, WANG Hong-yang, GUO Xia
Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, China
Abstract：ObjectiveTo observe the effects of grape seed proanthocyandin extract(GSPE) on pulmonary ventilation and inflammation in elderly patients with obstructive sleep spnea-hypopnea syndrome(OSAHS). Methods From December 2012 to December 2014, 108 cases of OSAHS in Department of Respirology, Affiliated Hospital of North China University of Science Technology were divided into three groups: control group (36 cases), GSPE A group (36 cases) and GSPE B group (36 cases).The control group received continuous positive airways pressure (CPAP) treatment, while GSPE group A and GSPE group B respectivelyreceived high (100mg/capsule, 2 capsules/time) and low (100mg/capsule, 1 capsule/time) doses of GSPE treatment orally besides CPAP. Before treatment and 8 weeks after treatment, peripheral blood interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) were deteceted, and the maximum hypopnea time (MHT), low ventilation index (HI), the longest apnea time (LAT), apnea index (AI) and respiratory disturbance index (RDI), lowest oxygen saturation(LSaO2) were monitored by polysonmography (PSG).The data were statistically analyzed with SPSS17.0 software. Results Before the treatment, there were no significant differences in basic clinical data, PSG monitoring indexes, IL-6 and TNF-a levels among the patients of three groups (P>0.05). Compared with those before treatment, the MHT, HI, LAT, AI, RDI and LSaO2 in the control group and GSPE group A were significantly improved after treatment (P<0.05), so were the MHT, HI, RDI and LSaO2 in GSPE group B (P<0.05. After treatment, the MHT, HI, RDI and LSaO2 in GSPE group A and GSPE group B were more improved when compared with the control group (P＜0.05). So were for GSPE group A when compared with GSPE group B (P＜0.05). After treatment, the IL-6 and TNF-a levels in GSPE group A and GSPE group B were significantly lower than in the control group(IL-6: 20.10±5.96 and 26.33±6.38 vs. 33.14±7.22; TNF-a : 32.42±6.33 and 42.80±5.48 vs. 51.32±4.28) (P<0.05). The effective rate of treatment in GSPE group A (88.2%)was higher than those in GSPE group B(81.8%)and control group(70.5%) (P＜0.05). Conclusions Grape seed proanthocyandin extract can effectively reduce IL-6 and TNF-α levels and promote the clinical treatment effects in elderly patients with obstructive sleep apnea-hypopnea syndrome.
2016, Vol. 23 
