Abstract：Objective To analyze the sensitivity of multi-drug resistant (MDR) Mycobacterium tuberculosis isolates in Changsha to antituberculosis drugs, so as to provide evidence for the treatment of multi-drug resistant tuberculosis(MDR-TB). Methods The absolute concentration indirect method was used to test the drug resistance of 155 clinical isolates of Mycobacterium tuberculosis to first-line and second-line antituberculosis drugs. Their drug resistance was retrospectively analyzed. Results The first-line and second-line antituberculosis drugs withdrug resistance rates in descending order in the 155 clinical isolates of Mycobacterium tuberculosis were as follows: streptomycin,ethambutol, levofloxacin,p-aminosalicylic acid,cethionamide,amikacin and pyrazinamide. Their drug resistance rates were 70.32%, 36.13%, 20.65%, 12.90%, 8.39% , 3.87％ and 3.87％ in turn. 46 strains were detected to be resistant to two drugs, mainly streptomycin and ethambutol, with the drug resistance rate of 29.68%. 18 strains were resistant to three drugs, mainly streptomycin, ethambutol and levofloxacin, with the drug resistance rate of 11.61%. 5 strains were resistant to four drugs, mainly streptomycin, ethambutol, levofloxacin and cethionamide, with the drug resistance rate of 3.23%. One isolate was resistant to five drugs and two to six. Conclusions The resistance of multi-drug resistant tuberculosis to first-line and second-line antituberculosis drugs is serious in Changsha in 2014,which brings great challenge to the cure of multi-drug tuberculosis patients.
2016, Vol. 23 
