Abstract：Objective To investigate the distribution features and antimicrobial resistance profiles of clinical isolates from the Third Xiangya Hospital of Central South University in 2015 so as to provide evidence for rational use of antibiotics in clinical practice. Methods Clinical isolates from the Third Xiangya Hospital of Central South University from January to December, 2015 were collected. Vitek-2 automated microorganism identification system was used to identify the isolates and to test the antimicrobial resistance. All the data were analyzed by WHONET 5.6 software according to CLSI 2013 breakpoints. Results Of the 4,801 isolates collected in this study, Gram negative organisms and Gram positive cocci accounted for 67.19% (3,226/4,801) and 32.81% (1,575/4,801) respectively. The sensitivity rates of Enterobacteriaceae strains to β-Lactamaseinhibitors and carbapenems were > 80%. The resistant rates of Acinetobacter baumannii and Pseudomonas aeruginosa to imipenem were 41.4% and 74.8% respectively.The detection rates of MRSA in Staphylococcus aureus and Staphylococcus epidermidis were 70.9% and 76.7% respectively. Staphylococcus isolates were highly resistant to β-Lactamase inhibitors, macrolides and fluoroquinolones. The sensitivities of Fecal streptococcus to most of antibiotics were higher than those of Enterococcus faecium. Conclusions Most of the clinical isolates from the Third Xiangya Hospital of Central South University in 2015 are Gram negative bacilli. Bacterial resistance rate is still high, especially in Acinetobacter baumannii isolates; and hence, great attention should be paid to prevention of nosocomial infections.
2017, Vol. 24 
