Abstract：Objective To explore the changes of FoxM1 gene expression in pregnant women with gestational diabetes mellitus (GDM) and its relationship with insulin. Methods One hundred pregnant women with GDM and 100 normal pregnant women with antenatal examination in Department of Obstetrics, Shijie Hospital of Dongguan City were selected as the study group and control group respectively. Radioimmunoassay was used to determine the serum levels of insulin of the two groups, and RT-PCR was employed for detecting the expression of FoxM1 gene. Results On the diagnosis of GDM, the expression level of serum insulin in the study group was significantly higher than that in the control group (t=12.22, P<0.05). Six hours after delivery, the expression levels of serum insulin of the two groups both decreased, but that of the study group was still significantly higher than that of the control group (t=13.67, P<0.05). On the diagnosis of GDM, the expression level of FoxM1 mRNA was significantly higher in the study group than in the control group ((2.38±0.45) vs. (1.25±0.37), t=19.40, P<0.05). Six hours after delivery, the expression levels of FoxM1 mRNA of the two groups both decreased, but it was still significantly higher in the study group than in the control group ((1.39±0.27) vs. (0.74±0.16), t=20.71, P<0.05). The expression level of serum insulin in the study group was positively correlated with FoxM1 gene expression (r=0.56, P<0.05). Conclusions FoxM1 gene is involved in the pathogenesis of GDM, and its expression is positively correlated with the expression of serum insulin in pregnant women with GDM.
屈兰芹， 江颖茹， 袁兆章. 妊娠期糖尿病孕妇中FoxM1基因的表达及其与胰岛素的关系[J]. 实用预防医学, 2017, 24(1): 49-51.
QU Lan-qin, JIANG Ying-ru, YUAN Zhao-zhang. Expression of FoxM1 gene and its relationship with insulin in pregnant women with gestational diabetes mellitus. , 2017, 24(1): 49-51.
2017, Vol. 24 
