摘要 目的了解2010-2014年厦门市居民不同性别、年龄组的肝癌疾病负担及其变化趋势，为厦门市肝癌防治工作提供科学依据。 方法利用厦门市死因监测网络直报系统收集2010-2014年厦门市居民肝癌死亡数据，运用早死所致的健康生命损失年(years of life lost, YLL)、残疾所致的健康生命损失年(years lost due to disability, YLD)、伤残调整寿命年（disability adjusted life year, DALY）对肝癌疾病负担进行测量、分析。 结果2010-2014年厦门市居民肝癌粗死亡率为30.47/10万，标化死亡率31.96/10万；男性粗死亡率48.82/10万，标化死亡率52.77/10万；女性粗死亡率12.24/10万，标化死亡率12.32/10万, 五年来厦门市居民肝癌死亡率、标化率呈递减趋势（χ21=6.80，P1=0.009; χ22=1 074.39，P2=0.000）；2010-2014年，厦门市居民每千人口肝癌YLL、YLD、DALY分别为3.659、0.023、3.682年；男性(6.130、0.031、6.161年/千人)高于女性(1.204、0.012、1.216年/千人)，男、女性疾病负担高峰值分别在50~岁组(17.708、0.091、17.799年/千人)和60~岁组(3.894、0.046、3.940年/千人)。男性30岁开始YLL、YLD、DALY明显升高。 结论2010-2014年厦门市肝癌疾病负担逐年下降，YLL是厦门市居民肝癌疾病负担的主要来源，30岁以上男性以及50~69岁老年群体是肝癌重点防治人群。
Abstract：Objective To investigate the disease burden of liver cancer and its changing trend in residents of different genders and age groups in Xiamen City during 2010-2014 so as to provide scientific evidence for liver cancer prevention and therapy. Methods The network direct reporting system for death cause surveillance in Xiamen City was employed to collect the data of liver cancer deaths in the residents of Xiamen City from 2010-2014. The years of life lost (YLL), years lost due to disability (YLD) and disability adjusted life year (DALY) were used to assess its disease burden. Results The crude mortality rate of liver cancer in the residents of Xiamen City duirng 2010-2014 was 30.47/100,000, and the standardized mortality rate was 31.96/100,000. The crude mortality rate and the standardized mortality rate were 48.82/100,000, 52.77/100,000 for males and 12.24/100,000, 12.32/100,000 for females. The mortality rate and standardized mortality rate showed a declining tendency from 2010 to 2014 (χ21=6.80, P1=0.009; χ22=1,074.39, P2=0.0000). The YLL, YLD and DALY in 2010-2014 were respectively 3.659, 0.023 and 3.682 years per 1,000 persons, of which those in the males (6.130, 0.031 and 6.161 years per 1,000 persons) were all higher than those in the females (1.204, 0.012 and 1.216 years per 1,000 persons). The heaviest disease burden fell in the age group of 50- years for males (17.708, 0.091 and 17.799 years per 1,000 persons) and in the age group of 60- years for females(3.894, 0.046 and 3.940 years per 1,000 persons). The YLL, YLD and DALY in the males aged 30 years and above increased significantly. Conclusions The disease burden of liver cancer in Xiamen City decreases year by year from 2010 to 2014. The YLL is the main souce of disease burden. More attention should be paid to prevention and cure of liver cancer in the males aged 30 years and above and the elderly aged 50-69 years.
池家煌， 林艺兰， 伍啸青， 陈国伟， 罗文婷. 2010-2014年厦门市居民肝癌疾病负担分析[J]. 实用预防医学, 2017, 24(1): 9-11.
CHI Jia-huang, LIN Yi-lan, WU Xiao-qing, CHEN Guo-wei, LUO Wen-ting. Disease burden of liver cancer in residents in Xiamen City, 2010-2014. , 2017, 24(1): 9-11.
2017, Vol. 24 
