Factors influencing mother-to-child transmission of hepatitis B virus andefficacy of hepatitis B immunoprophylaxis in children at high risk of hepatitis B
LIU Zhao-qing*, ZHANG Xiao-xia
Hunan Provincial Maternal and Child Health Hospital, Changsha, Hunan 410008, China
Abstract：Objective To explore the efficacy of hepatitis B immunoprophylaxis and the factors influencing mother-to-child transmission of hepatitis B virus in children at high risk of hepatitis B so as to provide a basis for declining the infection rate of hepatitis B in children. Methods We retrospectively analyzed the clinical data regarding 431 HBsAg-positive mothers and their 452 children aged 1-5 years at high risk of hepatitis B hospitalized in Hunan Provincial Maternal and Child Health Hospital from August 2012 to January 2016. Hepatitis B markers in the children were detected, and the factors influencing mother-to-child transmission of hepatitis B virus and the efficacy of hepatitis B immunoprophylaxis were analyzed. Results The 452 children at high risk of hepatitis B all received a full course of HBV vaccination, and 94.91% (429/452) were injected with hepatitis B immunoglobulin (HBIG). The infection rate of HBsAg was 4.20% (19/452) for total, and significantly lower in children with combined immunization (1.40%, 6/429) than in those with single immunization (56.52%,13/23) (P=0.000). It was not significantly different among different age groups (P=0.971). HBsAb positive rate decreased gradually with the increase of age (P=0.000). Univariate analysis showed that HBeAg-positive mothers and HBV-DNA copy ≥ 106 could result in higher infection rate in the high risk children (P=0.000). Multivariate logistic regression analysis showed that HBeAg-positive mothers and HBV-DNA copy ≥ 106 were the independent risk factors of mother-to-child transmission of hepatitis B virus. Conclusions HBeAg-positive mothers and HBV-DNA copy ≥ 106 are the independent risk factors for mother-to-child transmission of hepatitis B virus. It is necessary to strengthen prevention and intervention during pregnancy so as to decline the infection rate of hepatitis B in infants. More attention should be paid to intensify HBsAb monitoring during the growth and development of children at high risk of hepatitis B and maintain the antibody level against hepatitis B virus.
刘沼清，张晓霞. HBV母婴传播影响因素及乙肝高危儿免疫预防的效果观察[J]. 实用预防医学, 2017, 24(11): 1344-1346.
LIU Zhao-qing, ZHANG Xiao-xia. Factors influencing mother-to-child transmission of hepatitis B virus andefficacy of hepatitis B immunoprophylaxis in children at high risk of hepatitis B. , 2017, 24(11): 1344-1346.
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2017, Vol. 24 
