Abstract：To investigate the indicators of fluoride bone injury risk assessment in endemic fluorosis areas, forecast disease distribution, analyze the risk factors by risk assessment, provide the basis for the fluorine hazard control strategies. Methods By field epidemiology survey, analyze the relationship between the drinking water fluoride, daily fluoride intake, cumulative total fluoride intake, urine fluoride, the incidence of fluoride bone injury, evaluate the dose-response relationship, get the BMD, BMDL, RfD of fluoride bone injury risk factors on certain exposure levels. Results The incidence of fluoride bone injury increases with the increase in drinking water fluoride, daily fluoride intake, cumulative total fluoride intake, urine fluoride, linear trend is clearly, the differences were statistically significant. The BMD of drinking water fluoride, daily fluoride intake, urine fluoride are1.43mg/L, 4.47mg/, 1.90mg/L; BMDL are1.19mg/L, 2.94mg/, 1.77mg/L; RfD are0.60mg/L, 2.94mg/, 1.77mg/L. Conclusions The fluoride bone injury risk of population exposed to endemic fluorosis is still closely related with drinking water fluoride, daily fluoride intake, cumulative total fluoride intake, urine fluoride after the change of water. To reduce the risk of fluoride bone injury, we propose to strengthen the water improvement measures combined with fluoride exclude, lifestyle change, improving nutrition structure
[1] 黎昌健,蒙衍强,蒋才武.地氟病在中国大陆的流行现状[J].实用预防医学,2008,15（4）：1295-1298. [2] Junxiang Ma,Mingfeng Li,Jun Tu,et al. Serum osteocalcin and calcitonin in adult males with different fluoride exposures[J]. Fluoride,2009,42(2)：133-136. [3] 向全永,张明访,洪沛,等.总摄氟量与儿童氟斑牙相关关系研究[J].中国地方病防治杂志,2007,22（4）：254-257. [4] Gaylor D,Ryan L,Krewski D,et al. Procedures for calculating benchmark doses for health risk assessment[J]. Regul Toxicol Pharmacol,1998,28(2)：150-164. [5] Nahum A.Medellin-Castillo,Roberto Leyva-Ramos,Raul Ocampo-Perez,et al.Adsorption of Fluoride from Water Solution on Bone Char[J].Ind Eng Chem Res,2007,46（26）：9205-9212. [6] 姬海莲.铝电解厂周围地区人群氟斑牙和尿氟水平调查[J].环境与健康杂志,2006,23（6）：520-521.
2014, Vol. 21 
