Abstract：Objective To study the infection rate and drug resistance rate of Ureaplasma urealyticum and Mycoplasma hominis in infertility patients in this area, and to select the appropriate antibiotics to treat the pathogenic organisms. Mothods 4 266 specimens from infertility patients in the fertility clinics were cultured for UU and Mh, and 1 557 cases of positive samples were taken a drug sensitive test to know the drug resistance rate. Results The total infection rate of mycoplasma in infertility patients was 36.5%. Infection rate of UU was significantly higher than that of Mh. Infection rate in women was 45.4%, which was significantly higher than that in men. Drug sensitive test results showed that genital tract mycoplasma was relatively high resistant to quinolone antibiotics, and more sensitive to macrolide antibiotics and tetracycline class antibiotics. The risistence rate of Mh to most antibiotics was high in the study, except minocycline、doxycycline、Josamycin and tetracycline. Conclusion Infertility patients had high infectious rate to UU and Mh. Mycolasma had definite resistence to commonly used antibiotics, and clinicians should use antibiotics based on the drug sensitivity results.
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