Abstract：Objective To confirm the role of CD4+ / CD8+ T cell (CD4/CD8) ratio in early diagnosis of infant human immunodeficiency virus (HIV) infection via mother-to-child transmission and to provide the basis for clinical application. Method The anticoagulated whole blood samples were collected in 2011-2013 from 115 cases of infants 3-11 months of age born to HIV-positive mothers, and the CD4+T cells and the HIV-1 DNA were detected. Results Of the 115 infants, 5 cases were positive for HIV-1 DNA and the positive rate was 4.34%. Analysis of the CD4/CD8 ratio got a consistent result with HIV-1 DNA detection, the ratio <1.0 for the 5 positive cases. The percentages of CD4 + T cells were all above 25% for the 115 cases. Among the 110 cases of the HIV-1 DNA-negative infants, the CD4+ T cell absolute numbers of 2 cases were <1500 cells /µl blood, while among the 5 HIV-1DNA-positive cases, one was <1500 cells /µl blood and 4 were >1500 cells /µl blood. Conclusion The CD4/CD8 ratio <1.0 could be judged as HIV positive in early diagnosis of infant HIV infection via mother-to-child transmission.
李向忠,贺健梅,张国强,彭谨瑜,丁丽莎,邹潇白,江洋,陈曦. CD4 + / CD8+ T细胞比值在HIV-1母婴传播早期诊断的应用[J]. 实用预防医学, 2014, 21(10): 1177-1178.
LI Xiang-zhong, HE Jian-mei, ZHANG Guo-qiang. CD4 + / CD8+ T cell ratio in the early diagnosis of mother-to-child HIV-1 transmission. , 2014, 21(10): 1177-1178.
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