Abstract：Objective To discuss the effect of using of glucocorticoids (GCs) on the patient's condition of hand, foot and mouth disease(HFMD). Methods To use a retrospective cohort study, to reveal the Effect of Early Use of GCs on HFMD by comparing the differences in disease severity score between GCs exposure group and the non-exposed group. Results The proportion(22.73%) of aggravation of the exposed group was higher than that(10.45%) of non-exposed group(U=20096.5, P=0.00); The proportion(28.24%) of aggravation of Patients of early exposure group was higher than that(11.65%) of Patients of non-early exposure group(U=6669, P=0.00). The proportion(16.05%) of aggravation of light cases of exposure group was higher than that(7.80%) of light cases of non-exposed group (U=4799.5, P=0.01); The proportion(20.83%) of aggravation of light cases of early exposure group was higher than that(8.05%,) of light cases of non-early exposure group(U=3367, P=0.00). The proportion(62.59%) of aggravation of severe cases of exposure group was higher than that(15.19%) of severe cases of non-exposed group (U=4612.5, P=0.01); The proportion(32.53 %) of aggravation of severe cases of early exposure group was higher than that(16.30%) of severe cases of non-early exposure group (U=4550.5, P=0.00). There was a positive correlation between the degree of aggravation and doses of using GCs (rP=0.30, P=0.046) and between the degree of aggravation and the number of using GCs days(rP=0.32, P=0.02) in the exposure group. Conclusion There is a certain degree of risk of the disease progress for mild HFMD cases and severe HFMD cases with using GCs, especially early using of GCs. We recommend that mild cases shouldn’t be used GCs for therapy and for severe cases using GCs should be carefully.
吴泰顺,张宝莉,汪保国. 使用糖皮质激素对手足口病病情影响的回顾性队列研究[J]. 实用预防医学, 2014, 21(10): 1153-1156.
Wu Taishun, Zhang Baoli, Wang Baoguo. The Retrospective Cohort Study on the Effect of Use of Glucocorticoids on the Hand, Foot and Mouth Disease. , 2014, 21(10): 1153-1156.
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