Abstract:Objective:In this study, we investigated the existance of lactobacillus in the vaginal discharge of the postoperative cervical cancer patients before-and-after radiation therapy , and the resistance of lactobacillus to 4 antibiotics, to provide evidences for preventing and treating the secondary infections after operation fcervical cancer. Methods:A germiculture method was employed. Lactobacillus from the vaginal discharge samples of the cervical cancer patients before and after radiation therapy were cultured for statistic and drug sensitive test. Results:The detection rate of lactobacillus before radiation therapy was 76.98%, higher than that after radiation therapy (45.24%), The result was statistically significant ( P < 0.05). The resistance of lactobacillus to 4 antibiotics in vitro were, cefotaxime sodium 4.7% , amikacin 5.8%, gentamycin 76.8%, metronidazole 84.5%, respectively. The result showed that lactobacillus was most sensitive to cefotaxime sodium and was most resistant to metronidazole.Conclusion:Radiation therapy after cervical cancer operation leads to micro-ecological imbalance in vagina, which may play a key role in the secondary infections of postoperative patients. Our study implicated that metronidazole can be the first choice to prevent infections after radiation therapy because of the high resistance of probiotics such as lactobacillus to it, and cefotaxime sodium should be avoided in treatment for vaginal infections.
张彩霞,苟占彪,车团结,张莹,冯海霞. 宫颈癌患者放疗前后乳酸菌的变化及药敏分析[J]. 实用预防医学, 2015, 22(8): 1004-1006.
ZHANG Cai-xia, GOU Zhan-biao, CHE Tuan-jie, ZHANG Ying, FENG Hai-xia. Study the changing of lactic acid bacteria and drug sensitivity analysis pre and post chemotherapy in patients with cervical cancer. , 2015, 22(8): 1004-1006.