Abstract:Objective Understand the characteristics of Japanese encephalitis (JE) and antibody levels of healthy population in Shijiazhuang.Analyze the relationship between the incidence of JE and population immunity levels. Methods The JE cases from 2000 to 2014 were analyzed by descriptive epidemiology. Select monitoring points by cluster sampling method in 2003,2013 and 2014. Collect healthy human serum samples total 8 age group. To detect antibodies IgG through indirect ELISA method. Results Since 2000 to 2012, the incidence of JE is in the single digits.120 cases outbreak occurred in 2013. Onset concentrated in October accounted for 63.92 percent.The highest incidence of groups are 50- and 60-. Mainly cases are farmers. The rates of healthy population antibody positive is 30.89%, 13.41% and 65.02% respectively in 2003,2013 and 2014. The JE antibody positive rate in different years and different age groups was statistically significant. The antibody levels in low prevalence year is mainly affected by the immunization effect.After a high prevalence year , affected by latent infection , the overall antibody level is increasing. Conclusion Except 2013,Since 2000 the JE incidence remained at a low level in Shijiazhuang.We should keep a long-term monitor and improve the quality of vaccination and inoculation rate to increase population’s immunity levels.