1. Depatrment of Preventive Medicine,School of Public Health and Management, Guangxi University of Chinese Medicine, Nanning, Guangxi 530000, China; 2. Institute for Health Toxicology and Function Test, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, Nanning, Guangxi 530000, China
Abstract：Objective To study the effect of sericin on blood glucose in hyperglycemic model mice. Methods Hyperglycemic model mice of the treatment groups received 250, 500 and 1,000 mg/kg body weight of sericin by gavage for 30 days, respectively. The model control group was given the same volume of pure water. The effect of sericin on blood glucose and body weight in mice was observed. Results Compared with the model control group, sericin had no obvious effect on hyperglycemic model mice’s body weights at all stages (P>0.05). The decrease value and reduction percentage of blood glucose in the sericin treatment groups were significantly higher, with statistically significant differences (P<0.05). The areas under the glucose curves of 1,000 mg/kg and 500 mg/kg dose groups were significantly lower, showing a statistically significant difference (P<0.05). Sericin had no significant effect on blood glucose of normal mice. Conclusion Sericin has an auxiliary hypoglycemic effect on hyperglycemic model mice under the experimental conditions of the present study, and it has the potential to be developed into a new resource food with auxiliary hypoglycemic and hypolipidemic effects.
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2023, Vol. 30 
