1. Futian District Center for Disease Control and Prevention, Shenzhen, Guangdong 518040, China; 2. Shenzhen Maternity and Child Healthcare Hospital Affiliated to Southern Medical University, Shenzhen, Guangdong 518040, China
Abstract：Objective To evaluate the effect of influenza vaccination among primary and secondary school students, to conduct an evaluation on health economics of vaccination, and to provide a basis for formulating influenza vaccination strategies. Methods The susceptible-exposed-infectious/asymptomatic-removed/recovered (SEIARR) dynamic model was used to simulate past epidemic data. The cumulative attack rate was calculated to evaluate the effect of vaccination, and the cost-effectiveness and cost-benefit were calculated for appraising health economics. Results When the influenza vaccination rates were 0%, 50%, 70% and 90%, respectively, the average cumulative attack rates of the epidemic were 99.79% (99.75, 99.82), 70.84% (70.58, 71.09), 56.81% (56.17, 57.45) and 34.29% (32.46, 36.20), respectively. The higher the influenza vaccination rate, the lower the cumulative attack rate. When the vaccination rates were 50%, 70% and 90%, respectively, the cost-effectiveness ratios of the vaccine were 141.03 (139.86, 142.19) yuan, 133.16 (131.34, 135.08) yuan and 112.90 (110.03, 116.11) yuan, respectively, and the cost-benefit ratios of the vaccine were 6.27 (6.22, 6.32) yuan, 6.65 (6.56, 6.74) yuan and 7.88 (7.66, 8.09) yuan, respectively. The higher the influenza vaccination rate, the better the cost-effectiveness and cost-benefit of the vaccine. Conclusion Influenza vaccination can effectively reduce the cumulative attack rate of the epidemic, and increasing the vaccination rate can effectively improve the health economic effect of vaccination.
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