Abstract:Objective To understand the regional characteristics of coronavirus disease 2019 (COVID-19) epidemic in Henan province, to analyze the differences in prevention and control details, and to provide references for the next step in epidemic prevention and control in urban and rural areas. Methods According to different regions, cities and villages, descriptive epidemiological methods were used for statistical analysis of COVID-19 cases reported in Henan province from January 21 to March 8, 2020. Results As of March 8, 2020, 1,272 confirmed cases and 22 deaths of COVID-19 were reported accumulatively in Henan province. Confirmed cases were reported in 18 prefecture-level cities of the province, affecting 147 counties or districts (84.97%, 147/173) and 596 township streets (23.66%, 596/2,519). Xinyang city, Nanyang city, Zhumadian city, Zhengzhou city and Shangqiu city reported more cases and clustered events and were considered as the key prevention and control areas. There were 250 clustered events, and most of them were family gathering (accounting for 85.20%). 21.60% of the clustered events did not find a clear source of infection, of which Shangqiu city, Pingdingshan city and Zhengzhou city accounted for a high proportion. 613 (48.19%) cases were found in cities, with a high proportion of cases in 6 prefecture-level cities such as Zhengzhou city and Pingdingshan city. 629 (49.45%) imported cases were reported, with a high proportion of cases in 6 prefecture-level cities such as Zhumadian city and Kaifeng city. According to the constituent ratio of the imported cases, the 18 prefecture-level cities were divided into three types of regions for performing the analysis, and statistically significant differences were found in the constituent ratios of the imported cases and the local cases between urban and rural areas as well as between aggregated and sporadic cases. Conclusions Under the condition that the overall prevention and control strategy remains unchanged, the complex characteristics of cities themselves such as residence, transportation and commercial exchanges, and the high risk of overseas import, determine the need to adopt more refined prevention and control measures. Patients with mild and asymptomatic COVID-19 are difficult to be diagnosed and isolated, and easy to cause transmission. Therefore, serological testing can be carried out to trace the source and contacts.