1. Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, Hunan, China 2. Chinese Center for Disease Control and Prevention, Beijing 102206, China
Abstract：Objective To understand the pathogenic biological characteristics, drug sensitivity and pulsed-field gel electrophoresis (PFGE) typing characteristics of Neisseria meningitides serogroup B isolated in Hunan province. Methods The drug sensitivity test and PFGE typing were carried out on 29 Neisseria meningitides serogroup B strains which were identified biochemically and serologically. Resultss Twenty-nine Neisseria meningitidis serogroup B strains were all sensitive to minocycline, ceftriaxone, cefotaxime, meropenem, rifampicin, chloramphenicol and azithromycin, and their sensitivities to penicillin and ampicillin were 75.86% and 86.21%, respectively. They were highly resistant to ciprofloxacin (34.48%), levofloxacin (41.38%) and compound sulfamethoxazole (96.55%). 29 Neisseria meningitidis serogroup B strains were divided into 22 bands by PFGE typing, and the isolates in different regions showed the same band pattern. Conclusions The sensitivities of Neisseria meningitidis serogroup B strains to antibacterial drugs were basically consistent with those of other serogroups, and PFGE typing presented highly different types. There was a certain genetic correlation between PFGE bands in healthy people and patients. We should continue to carry out molecular typing monitoring and pay close attention to the spread of strains.
2019, Vol. 26 
