Abstract:Different doses of ionizing radiation can damage cardiovascular system by different pathways. High doses of ionizing radiation can directly cause damage to microvascular endothelial cell barrier function, affect the expression of cell adhesion molecules and other biological macromolecules, and lead to chronic microvascular endothelial cell injury, such as inflammatory cell infiltration, fibrosis and necrosis. And the damaging effect will break the environmental homeostasis in the circulatory system and induce early cardiovascular disease gradually. Low-dose ionizing radiation-induced cardiovascular system damage is mainly due to abnormal DNA methylation and oxidative stress, and the resulting metabolites, such as reactive oxygen species (ROS) and homocysteine (Hcy), can cause chronic damage to cardiovascular system. The accumulation of secondary effect metabolites caused by continuous exposure to ionizing radiation will aggravate the tendency of cardiovascular system damage.
闫鹏, 郑代丰, 章群. 电离辐射心血管系统损伤途径的研究进展[J]. 实用预防医学, 2018, 25(5): 635-637.
YAN Peng, ZHENG Dai-feng, ZHANG Qun. Research progress on the pathways of cardiovascular system injury caused by continuous exposure to ionizing radiation. , 2018, 25(5): 635-637.
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