Abstract：Objective To evaluate the rubella antibody level and immune effect of rubellavaccine among healthy population in Xicheng District of Beijing in 2012, and to provide a scientific basis for preventing and controlling rubella and improving its immunization strategy. Methods Ten communities were randomly selected in Xicheng District of Beijing in 2012 to serve as the survey sites. A total of 220 serum samples were collected from local and floating healthy populations who had lived in Xicheng District for more than 6 months. ELISA was used to determine the IgG antibody against rubella; meanwhile, the vaccination history, disease history and demographic characteristics were investigated. Results The rubella antibody positive rate was 90.00%, and the geometric mean concentration (GMC) was 40.78 IU/ml. No statistically significant differences were found in the rubella antibody positive rate and GMC among populations with different genders and different household registration(both P>0.05). The rubellaantibody positive rate and GMC were both higher in populations with vaccination history than those without (both P<0.001). 5 years after rubella vaccination, the positive rate of rubella antibody still retained at high level. The antibody positive rate and GMC in populations from different age groups were statistically different (P<0.05). The rubella antibody positive rates of the age groups of 1.5-, 6-, 15- and 35- years ranged between 95.45% and 100%, but that of the age group of 25-<35 years was 88.64%, which was lower than those of the other age groups (P<0.05). The GMC of antibody against rubella was gradually decreased with the increasing age and years after immunization. Conclusions The rubella vaccine has a good immune persistence. The rubella antibody positive rate in healthy people in Xicheng District of Beijing in 2012 remained at a high level, whichpredicted that rubella outbreak would not occur recently in Xicheng District. It is necessary to constantly strengthen rubella surveillance and intensify its immunization among women of childbearing age when there are signs of rubella epidemic so as to prevent the occurrence of congenital rubella syndrome
王庆,王兆华,史淑芬. 2012年北京市西城区健康人群风疹抗体水平调查及疫苗免疫效果分析[J]. 实用预防医学, 2018, 25(4): 455-457.
WANG Qing, WANG Zhao-hua, SHI Shu-fen. Rubella antibody level and immune effect of rubella vaccine among healthy population in Xicheng District of Beijing, 2012. , 2018, 25(4): 455-457.
2018, Vol. 25 
