Abstract：Trichloroethylene is commonly used as a cleaning agent in the industry, and workers with occupational medicamentosa-like dermatitis induced by trichloroethylene exposure occupy a great proportion in occupational injuries. It is very difficult to control occupational medicamentosa-like dermatitis induced by trichloroethylene in the process of occupational disease prevention and treatment because of the differences in individual susceptibility and its unclear pathogenesis. MicroRNA is a small non-coding RNA molecule with about 22 nucleotides in length, which involves in the regulation of growth and development of the body, physiology and pathology. This article reviews the target genes directly or indirectly involved in the toxicity mechanism of regulation of exogenous chemicals based on the current basic studies on the regulation of microRNA gene expression, and provides clues for analyzing microRNA expression spectrum of occupational medicamentosa-like dermatitis induced by trichloroethylene.
刘金梅, 朱志良, 黄厚今. microRNA表达谱在职业性三氯乙烯药疹样皮炎研究中的应用[J]. 实用预防医学, 2017, 24(9): 1143-1147.
LIU Jin-mei, ZHU Zhi-liang, HUANG Hou-jin. Application of microRNA expression profiles to the study of occupational medicamentosa-like dermatitis induced by trichloroethylene. , 2017, 24(9): 1143-1147.
[1] 倪秀贤,谢谦怀,黄璐,等.深圳市某街道2010-2014年使用三氯乙烯企业职业危害状况[J].公共卫生与预防医学,2015,26(1):81-82. [2] 刘松,廖日炎,张红开,等.深圳光明新区2013-2015年三氯乙烯作业场所危害状况及劳动者健康分析[J].实用预防医学,2016,23(8):984-986. [3] 唐小江,李来玉,陈秉炯,等.职业性药疹样皮炎的研究进展[J].中华劳动卫生职业病杂志,2000,18(2):111-113. [4] Guha N, Loomis D, Grosse Y, et al. Carcinogenicity of trichloroethylene, tetrachloroethylene, some other chlorinated solvents, and their metabolites[J]. Lancet Oncol,2012,13(12):1192-1193. [5] 钟逸菲.东莞市2002-2009年三氯乙烯致急性中毒和职业性药疹样皮炎的分析[J].中华劳动卫生职业病杂志,2011,29(10):770-772. [6] 谭广辉.某市109例TCE药疹样皮炎病例的职业流行病学调查[J].中外健康文摘,2010,21(7):141-142. [7] 林凯平,吴子俊.深圳龙岗区1995-2005年三氯乙烯职业危害调查[J].中国热带医学,2006,6(4):716-717. [8] 朱志良,王德明,肖惠贞,等.职业性三氯乙烯中毒分析[J].现代预防医学,2005,32(4):378-380. [9] 李来玉,黄汉林,何家禧,等.广东150例职业性三氯乙烯药疹样皮炎病例的职业流行病学调查[J].中国职业医学,2006,33(5):333-336. [10] 中华人民共和国卫生部.GBZ 2.1-2007工作场所有害因素接触限值[S].北京:人民卫生出版社,2007:1-5. [11] 中华人民共和国卫生部.GBZ 38-2006职业性急性三氯乙烯中毒诊断标准[S].北京:人民卫生出版社,2006:1-6. [12] 中华人民共和国卫生部.GBZ 185-2006职业性三氯乙烯药疹样皮炎诊断标准[S].北京:人民卫生出版社,2006:1-5. [13] 胡明霞.三氯乙烯的毒理学研究新进展[J].国外医学,2001,22(3):155-158. [14] 徐新云,李学余,刘月峰,三氯乙烯致细胞免疫和体液免疫参与的混合型变态反应研究[J].中华劳动卫生职业病杂志,2014,32(12):881-886. [15] Wang G, Konig R, Ansari GA, et al. Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via activation of CD4 + T cells[J]. Free Radic Biol Med,2008,44(7):1475-1482. [16] 夏丽华,黄汉林,邝守仁,等.三氯乙烯所致药疹样皮炎50例临床分析[J].中华劳动卫生职业病杂志,2006,22(6):207-210. [17] Zhang L, Bassig BA, Mora JL, et al. Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene[J]. Carcinogenesis,2013,34(4):799-802. [18] 黄汉林,李来玉,陈秉炯.广东省三氯乙烯职业危害新问题研究进展[J].中国职业病医学,2002,29(1):2-3. [19] 徐新云,刘月峰,易娟,等.三氯乙烯药疹样皮炎患者免疫相关基因的表达水平[J].中华劳动卫生职业病杂志,2011,29(11):816-819. [20] 徐新云,李学余,刘月峰,等.三氯乙烯致细胞免疫和体液免疫参与的混合型变态反应研究[J].中华劳动卫生职业病杂志,2014,32(12):881-886. [21] 徐新云,陈冠豪,武南,等.CYP2E1和CYP1A1及白细胞介素-4基因多态性与三氯乙烯药疹样皮炎的关系[J].中华劳动卫生职业病杂志,2009,27(2):71-73. [22] 李森华,付艳艳,黄汉林,等.三氯乙烯药疹样皮炎患者外周血淋巴细胞趋化因子受体基因表达[J].中国职业医学,2008,35(6):200-202. [23] 李来玉,冷曙光,郑玉新,等.三氯乙烯药疹样皮炎代谢酶基因多态性的病例对照研究[J].中国职业医学,2002,29(1):4-8. [24] 臧丹,易娟,董海燕,等.细胞因子表达水平与三氯乙烯药疹样皮炎的关系[J].中华预防医学杂志,2012, 60(9):836-839. [25] Li H, Dai Y, Huang H, et al. HLA-B*1301 as a biomarker for genetic susceptibility to hypersensitivity dermatitis induced by trichloroethylene among workers in China[J]. Environ Health Persp,2007,115(11):1553-1556. [26] 程娟,刘强,施建,等.代谢酶基因多态性与三氯乙烯作业工人染色体损伤关系的研究[J].工业卫生与职业病,2013,39(1):31-35. [27] Bartel DP, Chen CZ. MicroRNA:genomics, biogenesis, mechanism, and function[J]. Cell,2004, 116(2):281-298. [28] Suarez Y, Fernandez-Hernando C, Pober JS, et al. Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells[J]. Circ Res,2007,100(8):1164-1173. [29] Cullen BR. Transcription and processing of human microRNA precursors[J]. Mol Cell,2004, 16(6):861-865. [30] 王冲.MicroRNA研究热点的分析[D].北京:北京协和医学院,2012. [31] 李俊杰.乙醇对肝细胞色素P-450氧化酶2E1的诱导[J].中国病理生理杂志,2003,19(2):193-193,202. [32] Mohri T, Nakajima M, Fukami T, et al. Human CYP2E1 is regulated by miR-378[J]. Biochem Pharmacol,2010,79(7):1045-1052. [33] Kimura S, Kozak CA, Gonzalez FJ, et al. Identification of a novel P450 expressed in rat lung:cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene [J]. Biochemistry,1989,28(9):3798-3803. [34] Jalas JR, Hecht SS, Murphy SE, et al. Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen[J]. Chem Res Toxicol,2005,18(2):95-110. [35] Kalscheuer S, Zhang XX, Zeng Y, et al. Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone[J]. Carcinogenesis, 2008,29(12):2394-2399. [36] Shen YL, Jiang YG, Greenlee AR, et al. MicroRNA expression profiles and MiR-10a target in anti-benzo[a] pyrene-7, 8-diol-9, 10-epoxide-transformed human 16HBE cells[J]. Biomed Environ Sci,2009,22(1):14-21. [37] Gong J, Wu YL, Zhang XT, et al. Comprehensive analysis of human small RNA sequencing data provides insights into expression profiles and miRNA editing[J]. RNA Biol,2014,11(11):1375-1385. [38] 张航.TCE致L-02肝细胞毒性中SET 相关的表观遗传调控机制的初步研究[D].深圳:深圳大学,2015.
2017, Vol. 24 
