Abstract：Objective To explore the effects of single exposure and co-exposure to heavy metals like mercury, lead and cadmium on essential hypertension. Methods In July-December 2016, 592 permanent residents were selected from 2 communities in Taiyuan City, Shanxi Province to serve as the research subjects. A face-to-face questionnaire survey was conducted to collect their general information and data about chronic diseases like essential hypertension. At the same time, fasting blood and morning urine specimens of the subjects were collected, inductively coupled plasma mass spectrometry technology was used to detect the inner exposure concentration of heavy metals in biological samples, and automatic biochemical analyzers were employed to detect blood biochemical indicators. The dose-response relationship and interaction of essential hypertension with the three heavy metals were analyzed by non-conditional logistic regression and Bayesian kernel machine regression. Results The levels of urinary lead (Z=-2.660, P=0.008), different ages (χ2=13.128, P<0.001), BMI (χ2=34.635, P<0.001), blood total cholesterol (Z=-2.954, P=0.003) were statistically different between the two groups. Non-conditional logistic regression analysis indicated that hypertension was positively correlated with the level of urinary lead (OR=1.042, 95%CI:1.008-1.077) and cadmium (OR=1.077, 95%CI:1.005-1.154). Bayesian kernel machine regression analysis revealed a possible positive dose-response relationship between urinary lead and hypertension. Conclusion Lead and cadmium may be risk factors for hypertension, and relevant departments should strengthen the monitoring of heavy metal levels in the environment.
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2023, Vol. 30 
