Abstract：Objective To explore the expression variation and clinical significance of platelet membrane glycoprotein GPⅡb/Ⅲa and serum D-dimer in patients with preeclampsia and eclampsia. Methods Immune turbidimetric method and enzyme-linked immunosorbent assay (ELISA) were used to detect the expression variation of serum D-dimer and platelet membrane glycoproteins GPⅡ b/Ⅲ a in preeclampsia and eclampsia patients (the experimental group, n=40), normal full-term pregnant women (the late pregnancy group, n=40) and healthy non-pregnant women of childbearing age (the control group, n=40). Results The level of platelet membrane glycoprotein GP Ⅱb/Ⅲa (2.07±0.45%) and D-dimer (5.49±0.74 mg/L) of the experimental group within 24 hours after the admission were significantly higher than those of the control group and the late pregnancy group (F=345.27, F=818.54, P=0.00), but no statistically significant differences were found between the control group and the late pregnancy group (both P>0.05). In the experimental group, the levels of GP Ⅱb/Ⅲa (3.26±0.83%) and D-dimer (7.26±0.58 mg/L) of pregnant woman with severe preeclampsia and eclampsia were significantly higher than those of mild preeclampsia pregnant women (t=9.48,t=26.47, both P<0.05). 48 hours after delivery, the levels of GP Ⅱb/Ⅲa and D-dimer in the late pregnancy group and the experimental group were decreased obviously, while there were no statistically significant differences when compared with the control group (both P>0.05). Conclusions The levels of platelet membrane glycoprotein GP Ⅱb/Ⅲa and D-dimer in patients with preeclampsia are significantly increased with the progression of preeclampsia condition; and hence, combined detection of levels of platelet membrane glycoprotein GP Ⅱb/Ⅲa and D-dimer can be considered as the important predictors in diagnosing and monitoring the disease condition changes of preeclampsia patients.
李丽红, 黄素静, 肖泽兰, 莫培晖, 邓森林. 子痫前期及子痫患者中血小板膜糖蛋白GPⅡb/Ⅲa及血清D-二聚体表达变化及其临床意义[J]. 实用预防医学, 2017, 24(7): 879-881.
LI Li-hong, HUANG Su-jing, XIAO Ze-lan, MO Pei-hui, DENG Sen-lin. Variation and clinical value of platelet membrane glycoprotein GPⅡb/Ⅲa and serum D-dimer in patients with preeclampsia and eclampsia. , 2017, 24(7): 879-881.
2017, Vol. 24 
