Abstract：Objective To study the changes of plasma fibrin monomer (FM) and D-dimer (DD) levels and their clinical values in children with severe pneumonia. Methods Eighty-one children with severe pneumonia were divided into disseminated intravascular coagulation (DIC) group and non-DIC group according to the occurrence of DIC, and 30 healthy children served as the control group. Plasma FM and DD levels were detected, and then compared among the groups. Results There were statistically significant differences in the plasma FM and DD levels among the three groups (P=0.000). The plasma FM and DD levels were significantly higher in the DIC group and non-DIC group than in the control group (P<0.001), higher in the DIC group than in the non-DIC group (P<0.001). Among the children with severe pneumonia, the abnormal rates of FM and DD were significantly higher in the DIC group than in the non-DIC group(P=0.025 and P=0.000 respectively). Among the children with severe pneumonia in the non-DIC group, the abnormal rate of FM was significantly higher than that of DD (P=0.000), while among those in the DIC group, no statistically significant difference was found(P=0.234). Plasma FM level was positively correlated with the plasma DD level in the children with severe pneumonia (r=0.48, P=0.000). Conclusions There exist hypercoagulation and secondary hyperfibrinolysis in children with severe pneumonia. Fibrin monomer and D-dimer could be considered as the sensitive indicators in the early diagnosis of hypercoagulation and DIC in children with severe pneumonia
黄彩芝, 莫丽亚, 张新萍, 邓永超, 李爱国, 杨娟. 重症肺炎患儿血浆纤维蛋白单体与D-二聚体水平分析[J]. 实用预防医学, 2016, 23(9): 1063-1065.
HUANG Cai-zhi, MO Li-ya, ZHANG Xin-ping, DENG Yong-chao, LI Ai-guo, YANG Juan. Plasma fibrin monomer and D-dimer levels in children with severe pneumonia. , 2016, 23(9): 1063-1065.
2016, Vol. 23 
