Abstract：Objective To analyze the economic burden of chickenpox outbreaks and the benefits-cost of varicella vaccine immunization in schools in Longhua District of Shenzhen City, and to provide references for economic evaluation of varicella epidemic management. Methods The total economic burden of chickenpox epidemics was investigated and calculated from the individual and society perspective. The dynamics model of infectious diseases was used to estimate the incidence of the epidemics, and the effectiveness and benefit-cost ratio (BCR) of emergency vaccination were evaluated. Results A total of 188 chickenpox casesin schoolsin Longhua District in 2019-2020 were reported, with about 12 children affected in each outbreak. 90.96% of the children affected were treated by outpatient therapy, 89.89% of them got recovery within 15 days, and 77.13% were breakthrough cases. The average family economic burden was 1,744.41 Yuan, and the social and economic burden per person of each epidemic in the two years was 368.03 Yuan, with the total economic burden being 2,112.44 Yuan. The number of cases could be reduced by 90% when the proportion of emergency vaccination reached 50% in kindergartens and 80% in schools. Emergency vaccination within 0.5 incubation period after the first case of the disease could reduce the number of cases in kindergartens and schools to 7.11% and 9.21% of those not implemented. The BCR of emergency vaccination for each outbreak was more than 14 after accounting for the socio-economic burden. There was a statistically significant difference in the BCR between kindergartens and schools at different vaccination time (t=5.176, P<0.05), and the BCR of kindergartens was significantly higher than that of schools. Conclusion Emergency vaccination can reduce the heavy economic burden brought by chickenpox. A higher BCR can be achieved when immunization strategies are in place. The effect of emergency vaccination on control of chickenpox epidemics in kindergartens is more remarkable.
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2022, Vol. 29 
