Abstract：Objective To study the impact of different doses of vitamin D supplementation on sex hormone levels and perinatal outcomes of pregnant women with pre-pregnancy overweight. Methods Ninety pre-pregnancy overweight pregnant women who gave birth in Hubei Maternal and Child Health Care Hospital from October 2018 to October 2020 were selected as the research subjects. According to the random number table method, they were randomly divided into the high-dose group and the low-dose group (each n=45). Both groups received vitamin D treatment in the middle and late pregnancy. The low-dose group received 400 IU/D, while the high-dose group was given 1,600 IU/d. The abnormal rate of vitamin D after the treatment, the levels of sex hormones (follicle stimulating hormone (FSH), estradiol (E2) and luteinizing hormone (LH)), glucose and lipid metabolism (fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), triglyceride (TG) and serum total cholesterol (TC)) before and after the treatment were compared between the two groups. The general indicators and adverse perinatal outcomes of neonates in the two groups were compared. Results After the treatment, the abnormal rate of vitamin D was significantly lower in the high-dose group than in the low-dose group (40.00% vs. 62.22%), with a statistically significant difference (χ2=4.447, P<0.05). The levels of E2, FSH and LH in the high-dose group after the treatment were significantly higher than those of before the treatment and the low-dose group, showing statistically significant differences (all P<0.05). After the treatment, FBG and HbA1c in the high-dose group were significantly lower than those of before the treatment and the low-dose group, TG and TC were significantly higher than those of before the treatment, but lower than those of the low-dose group, with statistically significant differences (all P<0.05). The neonatal blood glucose (BG) and partial pressure of carbon dioxide (PCO2) in the high-dose group were significantly lower than those in the low-dose group, showing statistically significant differences (both P<0.05). The total incidence rate of adverse perinatal outcomes was significantly lower in the high-dose group than in the low-dose group (26.67% vs. 44.44%), with a statistically significant difference (χ2=3.986, P<0.05). Conclusion High-dose vitamin D treatment can significantly improve the expression ofsex hormones in the middle and late pregnancy in pre-pregnancyoverweight pregnant women, reduce the incidence rate of adverse perinatal outcomes, and it is worth promoting in clinical practice.
魏小英, 包婧, 杨琼. 不同剂量维生素D补充对孕前超重孕妇性激素水平及围产结局的影响[J]. 实用预防医学, 2021, 28(12): 1457-1461.
WEI Xiao-ying, BAO Jing, YANG Qiong. Effects of different doses of vitamin D supplementation on sex hormone levels and perinatal outcomes of overweight pregnant women before pregnancy. , 2021, 28(12): 1457-1461.
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2021, Vol. 28 
