Abstract:Objective To analyze the basic situation and survival of elderly HIV/AIDS patients with highly active antiretroviral therapy in Hubei Province. Methods The main epidemiological characteristics and survival status of elderly HIV/AIDS patients aged ≥ 50 years were retrospectively analyzed, and HIV/AIDS patients aged < 50 years served as the controls. A correlation analysis was conducted. The cumulative survival rate was calculated using the life table method. Kaplan-Meier cure described the survival curves of HIV/AIDS patients in the age groups of ≥ 50 and <50 years, and Cox proportional hazard model was applied to determining the main risk factors influencing mortality. Results There were 2,643 HIV/AIDS patients aged ≥ 50 years, and the average age of starting treatment was (58.49±7.1) years old. There were 7,725 HIV/AIDS patients aged < 50 years, and the average age of starting treatment was (34.43±8.68) years old. Most of HIV/AIDS patients in the two groups were males, the married or cohabitants, had acquired HIV heterosexually, had a educational background of junior middle school or below, had baseline CD4 cell counts of 0-200 cells/μl, were classified in WHO clinical stage I, and received an initial therapy with zidovudine/ stavudine, lamivudine and efavirenz/ nevirapine. The life table method showed that the cumulative survival rate of HIV/AIDS patients in the age group of ≥ 50 years decreased from 82.06% in the first year to 53.63% in the tenth year, and the cumulative survival rate of HIV/AIDS patients in the age group of < 50 years decreased from 97.48% in the first year to 94.2% in the tenth year. Log-Rank test revealed that the death risk of the age group of ≥ 50 years was higher than that of the age group of < 50 years (χ2=209.74, P<0.001). Cox multivariate analysis showed that the educational background, WHO clinical stage, baseline CD4 cellcounts and initial therapy were the risk factors for the death of HIV/AIDS patients in the age group of ≥ 50 years (P<0.05), whereas the educational background, marital status, route of infection, WHO clinical stage, baseline CD4 cell counts and initial therapy were the risk factors for the death of HIV/AIDS patients in the age group of < 50 years (P<0.05). Conclusions The survival rate of the elderly HIV/AIDS patients receiving antiviral treatment in Hubei Province is low; and hence, it is necessary to adopt the targeted measures according to the characteristics of the province combined with the features and death risk factors of the elderly so as to decline the elderly HIV/AIDS patients’ death risk and improve the survival rate.
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