Abstract：Objective To explore the effect of compliance with antiretroviral therapy on CD4+T-lymphocyte count in methadone outpatients. Methods Two hundred and sixteen drug addicts who suffered from AIDS and received antiretroviral therapy in methadone clinics in Shuimogou District, Urumqi City from September 2006 to December 2015 served as the research objects, and their compliance to antiretroviral medication was investigated through a questionnaire survey. The effect of adherence to antiretroviral therapy on CD4+ T-lymphocyte count was analyzed. Results The patients with good and poor compliance accounted for 56.94% and 43.06% respectively. After one year of treatment, the CD4+ T-lymphocyte count of patients with good compliance increased from (294.91±183.56)cells/mm3 before the treatment to (466.28±215.80)cells/mm3 after the treatment, with a statistically significant difference (P<0.05). No statistically significant difference was found in the CD4+ T-lymphocyte count of patients with poor compliance between before and after the treatment ((306.91±185.48)vs.( 293.97±192.83) cells/mm3, P>0.05). The multivariable logistic regression analysis showed that no statistically significant differences were observed in the correlations between gender, age, route of infection and CD4+ T-lymphocyte count after antiretroviral therapy in patients with good compliance (P>0.05). The multivariable logistic regression analysis indicated that the antiretroviral therapy-related knowledge (OR=2.369,95%CI:3.624-7.987), taking the medicine for requested times (OR=2.342, 95%CI: 3.259-6.421), at requested dosage (OR=2.688, 95%CI:5.632-8.145), and at requested timepoints (OR=3.256, 95%CI:6.014-9.875), long-term adherence without intermission as required (OR=4.123, 95%CI:6.984-11.251) and family member’s reminding of timely taking medicine (OR=1.987, 95%CI: 4.709-8.209) were significant factors influencing the CD4+ T-lymphocyte count (P<0.05). Conclusions CD4+ T-lymphocyte count is a good indicator reflecting AIDS patients’ compliance. Antiretroviral therapy-related knowledge, taking medicine for requested times, at requested dosage and at requested timepoints, long-term adherence without intermission as required and family member’s reminding of timely taking medicine are significant factors influencing the CD4+ T-lymphocyte count. Improving AIDS patients’ adherence to antiretroviral therapy plays a positive role in promoting the clinical therapeutic effect.
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2017, Vol. 24 
