Abstract：Objective To explore the risk of adverse perinatal outcomes in twin pregnancies affected by gestational hypertension (GH). Methods One hundred and ten cases of twin pregnancies complicated with GH in Department of Obstetrics, the Fifth People’s Hospital of Jingzhou City from August 2011 to April 2016 were selected as the observation group; meanwhile, 110 cases of normal twin pregnancies selected by the ratio of l:l in the same hospital served as the control group. The pregnancy outcomes of the two groups were investigated and recorded. Results The gestational weeks and the cesarean section rate were (35.30±2.42) weeks and 90.0% in the observation group and (38.13±3.11) weeks and 65.5% in the control group, and the paired comparison between the two groups showed statistically significant differences (both P<0.05). The complication incidence rates of premature rupture of membranes, premature birth, anemia and postpartum hemorrhage in the observation group were all significantly higher than those of the control group (12.7% vs. 2.7%, 37.3% vs. 5.5%, 65.5% vs. 30.9%, 12.7% vs. 1.8%, all P<0.05). The birth weight was significantly lower in the observation group than in the control group, while the incidence rates of twin transfusion syndrome, fetal growth restriction and neonatal asphyxia were significantly higher in the observation group than in the control group, and the paired comparison between the two groups showed statistically significant differences (all P<0.05). Conclusions Twin pregnancies are common nowdays. GH can shorten the pregnancy time of twin pregnancies and increase the risk of cesarean section and adverse perinatal outcomes; and hence, active management and prevention should be intensified.
[1] 武艳梅,陈奕.双胎妊娠222例临床分析[J].中国临床医生杂志,2015,43(1):81-84. [2] 王祥荣,冯丽萍.影响双胎妊娠分娩方式选择及危险因素的分析[J].中国妇幼保健,2015,30(8):1165-1167. [3] van Eerden L, van Oostwaard MF, Zeeman GG, et al. Terminating pregnancy for severe hypertension when the fetus is considered non-viable: a retrospective cohort study[J].Eur J Obstet Gynecol Reprod Biol,2016,1(206):22-26. [4] 莫莉菁,金聪聪,吴永跟,等.辅助生殖技术治疗后单卵双胎的发生、处理及妊娠结局[J].中华妇产科杂志,2015,22(8):586-590. [5] Luke B, Stern JE, Kotelchuck M, et al. Birth outcomes by infertility treatment: analyses of the population-based cohort: Massachusetts outcomes study of assisted reproductive technologies (MOSART)[J].J Reprod Med,2016,61(3-4):114-127. [6] 杜彧华,刘毅,胡茜.双胎妊娠绒毛膜性对孕妇妊娠期并发症及围生儿预后的影响及意义[J].医学综述,2016,22(13):2669-2671. [7] Bartnik P, Kosinska-Kaczynska K, Kacperczyk J, et al. Twin chorionicity and the risk of hypertensive disorders: gestational hypertension and pre-eclampsia[J].Twin Res Hum Genet,2016,19(4):377-382. [8] 王金光,乔宠,刘彩霞.双胎妊娠并发妊娠期高血压的危险因素[J].中国计划生育和妇产科,2016,8(1):3-5. [9] Bensdorp AJ, Hukkelhoven CW, van der Veen F, et al. Dizygotic twin pregnancies after medically assisted reproduction and after natural conception: maternal and perinatal outcomes[J].Fertil Steril,2016,106(2):371-377. [10] 周晶,李博,陈书强,等.体外受精-胚胎移植受孕与自然受孕双胎妊娠临床结局比较[J].生殖医学杂志,2016,25(4):331-335. [11] Santana DS, Cecatti JG, Surita FG, et al. Twin pregnancy and severe maternal outcomes: the World Health Organization multicountry survey on maternal and newborn health[J].Obstet Gynecol,2016,127(4):631-641. [12] 肖辉云,于佳,刘裕,等.妊娠期糖尿病不增加双胎妊娠不良围产结局风险[J].中华围产医学杂志,2016,19(5):345-349. [13] Kawabata K, Morikawa M, Yamada T, et al. Isolated pregnancy-induced anti-thrombin deficiency in a woman with twin pregnancy[J].J Obstet Gynaecol Res,2016,42(6):719-721. [14] 赵雪卉.双胎合并妊娠期肝内胆汁淤积症临床分析[J].实用预防医学,2012,19(3):413-414. [15] Jeve YB, Potdar N, Opoku A, et al. Donor oocyte conception and pregnancy complications: a systematic review and meta-analysis[J].Int J Obstet Gy,2016,123(9):1471-1480. [16] Yan G, Xie X, Wang Y, et al. Twin pregnancy after intracytoplasmic sperm injection in woman aged 49 using autologous oocytes by mild ovarian stimulation: a case report[J].Int J Clin Exp Med,2015,8(10):19506-19508. [17] 刘莉,吴丽莉.双胎妊娠绒毛膜性质对孕妇妊娠期并发症及围生儿预后的影响[J].中国医药导报,2015,12(1):71-73. [18] Mankee A, Petri M, Magder LS. Lupus anticoagulant, disease activity and low complement in the first trimester are predictive of pregnancy loss[J].Lupus Sci Med,2015,2(1):95-102. [19] 岳丹,陆虹.双胎妊娠阴道分娩母婴结局及相关因素分析[J].中国妇幼保健,2013,28(1):57-60. [20] 孟琳,高士友,郭玉佳,等.OHSS高危单胚胎移植与双胚胎移植不孕患者结局分析[J].实用预防医学,2011,18(11):2123-2124.
2017, Vol. 24 
