Abstract：Objective To study the association between oral hygiene status and oral cancer among non-smoking and non-drinking women. Methods We recruited 162 non-smoking and non-drinking female patients who were postoperatively pathologically confirmed as oral cancer in Department of Oral and Maxillofacial Surgery, the First People’s Hospital of Yibin City from October 2012 to September 2017. And 214 non-smoking and non-drinking healthy women were simultaneously selected from health examination center in the same hospital to serve as the control group. Oral hygiene related variables included the frequency of teeth brushing, number of teeth loss, poor prosthesis, regular dental visits and recurrent oral ulceration. Multivariate logistic regression model was used to analyze the association between the score of oral hygiene and the incidence of oral cancer in non-smoking and non-drinking female patients. Results Daily teeth brushing less than twice (OR=1.49, 95%CI:1.09-2.08), teeth loss more than or equal to 5 (OR=1.80, 95%CI:1.16-2.84), having poor prosthesis (OR=1.51, 95%CI:1.04-2.23), irregular dental visits (OR=1.74, 95%CI:1.16-2.57) and suffering recurrent oral ulceration (OR=7.29, 95%CI:3.98-13.35) were risk factors for oral cancer in non-smoking and non-drinking women (all P<0.05). Multivariate logistic regression analysis showed that the score of oral hygiene was associated with the occurrence of oral cancer in non-smoking and non-drinking female patients. The higher the score, the higher the risk (χ2=24.179, P<0.001). Conclusions There is a relationship between the status of oral hygiene and the occurrence of oral cancer in non-smoking and non-drinking women.
[1] Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012[J]. Int J Cancer, 2015, 136(5):E359-386. [2] Zhang SK, Zheng R, Chen Q, et al. Oral cancer incidence and mortality in China, 2011[J]. Chin J Cancer Res, 2015, 27(1):44-51. [3] 何保昌, 陈法, 蔡琳. 饮酒, 吸烟及其交互作用与口腔癌关系的病例对照研究[J]. 福建医科大学学报, 2014, 48(1):42-46. [4] Tsai ST, Wong TY, Ou CY, et al. The interplay between alcohol consumption, oral hygiene, ALDH2 and ADH1B in the risk of head and neck cancer[J]. Int J Cancer, 2014, 135(10):2424-2436. [5]Ahrens W, Pohlabeln H, Foraita R, et al. Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study[J]. Oral Oncol, 2014, 50(6):616-625. [6] 刘兵, 张爱泓, 张贞, 等. 口腔癌发病的危险性因素及血清炎症因子的变化情况分析[J]. 实用预防医学, 2018, 25(6):731-734. [7] 李生梅, 常群安. 喝茶对不吸烟饮酒人群口腔恶性肿瘤发病的影响[J]. 中国现代医学杂志, 2016, 26(8):95-98. [8] Kheur SM, Kheur M, Gupta AA. Oral prophylaxis as an adjunct procedure towards prevention and management of oral cancer: rationale and application[J]. Oral Oncol, 2014, 50(8):e44-45. [9] 赵湘, 孙正, 葛化冰. 口腔卫生习惯与口腔癌发生的相关性研究[J]. 首都医科大学学报, 2014, 35(2):253-256. [10] Melo P, Marques S, Silva OM. Portuguese self-reported oral-hygiene habits and oral status[J]. Int Dent J, 2017, 67(3):139-147. [11] 黄江峰, 何保昌, 陈法, 等. 口腔卫生状况及慢性病与口腔鳞状细胞癌的关系研究[J]. 中华预防医学杂志, 2015, 49(8):688-692. [12] Schmidt BL, Kuczynski J, Bhattacharya A, et al. Changes in abundance of oral microbiota associated with oral cancer[J]. PLoS One, 2014, 9(6):e98741. [13] Dholam KP, Chouksey GC. Squamous cell carcinoma of the oral cavity and oropharynx in patients aged 18-45 years: a case-control study to evaluate the risk factors with emphasis on stress, diet, oral hygiene, and family history[J]. Indian J Cancer, 2016, 53(2):244-251. [14] Feller L, Altini M, Lemmer J. Inflammation in the context of oral cancer[J]. Oral Oncol, 2013, 49(9):887-892. [15] 何保昌, 陈法, 刘芳萍, 等. 福建省非吸烟人群口腔癌发病影响因素病例对照研究[J]. 中国公共卫生, 2015, 31(10):1261-1265. [16] Chen F, He BC, Yan LJ, et al. Influence of oral hygiene and its interaction with standard of education on the risk of oral cancer in women who neither smoked nor drank alcohol: a hospital-based, case-control study[J]. Br J Oral Maxillofac Surg, 2017, 55(3):260-265.
2019, Vol. 26 
