Abstract：Objective To investigate the etiological and epidemiological characteristics of severe hand, foot and mouth disease (HFMD) in Jinan region in 2009-2013 so as to provide scientific evidence for HFMD prevention and control. Methods:RT-PCR technique was used to detect enterovirus 71 (EV71), coxsackievirus A16 (CVA16) and other enteroviruses in 138 specimens collected from severe HFMD cases in the sentinel hospital. All the data of severe HFMD cases were analyzed by descriptive epidemiological method.Results:Among 138 severe HFMD cases, 132 (95.65%) were positive for EV RNA, of which 86.36% (114/132) were positive for EV71, 6.82% (9/132) positive for CVA16 and 6.82% (9/132) positive for other enteroviruses. All of the severe HFMD cases were sporadic, and 74.64% of the cases occurred between May and August. Male cases of severe HFMD were significantly more than females ones (X2=48.75, P<0.01), and 84.06% of the severe HFMD cases were children aged less than 3 years. Conclusions:The severe HFMD cases show obvious population characteristics, and EV7l is the main pathogen for severe or dead HFMD cases in Jinan region during 2009-2013. It is necessary to pay more attention to the high-risk population, and the early recognition and timely intervention and treatment of severe cases are the keys to reduce the mortality rate.
王春荣, 关恒云, 韩秀云, 赵红, 吕燕, 刘岚铮. 2009-2013年济南地区重症手足口病病原学及流行病学分析[J]. 实用预防医学, 2015, 22(1): 60-62.
WANG Chun-rong, GUAN Heng-yun, HAN Xiu-yun, ZHAO Hong, LU Yan, LIU Lan-zheng. Analysis on etiology and epidemiology of severe hand, foot and mouth disease in Jinan region in 2009-2013. , 2015, 22(1): 60-62.
2015, Vol. 22 
