Abstract:Objective To explore the risk factors related to recurrence of endometriosis (EM) patients after operation so as to provide a basis for early prevention of EM relapse. Methods A 2-year follow-up survey was conducted in 348 EM patients with operation. According to the patients with or without EM recurrence, they were divided into the relapse group and the non-relapse group. The distribution of possible influencing factors was compared between the two groups, and influencing factors related to EM relapse after operation were screened. Results The rate of EM relapse in two years after operation was 16.7% (58/348). Single factor χ2 test and multiple factor logistic regression analysis showed that the risk factors for EM relapse after operation were having a history of dysmenorrhea (OR=3.080), having a history of previous uterine cavity operation (OR=4.183), pain nodule in posterior fornix of vagina (OR=3.557), surgical staging (OR=2.096), without medication after operation (OR=4.518) and non-pregnancy after operation (OR=1.931). Conclusions The risk factors affecting EM relapse in the patients include having a history of dysmenorrhea, having a history of previous uterine cavity operation, pain nodule in posterior fornix of vagina, surgical staging of high-grade EM, without postoperative medication and non-pregnancy after operation. It is necessary to adopt early prevention measures so as to decline the postoperative relapse rate of EM.