Abstract：Objective To explore the expression level of DNA in low methylation status in peripheral blood mononuclear cells (PBMC) of patients with systemic lupus erythematosus (SLE). Methods Forty patients with SLE hospitalized in the Third Xiangya Hospital from January to December 2015 were selected to divide into the remission phase group (SLEDAI<5) and the active phase group (SLEDAI≥5), with each n=20. At the same time, 20 healthy volunteers were selected as the control group. We determined the expression levels of mbd2 and CD11a in PBMC, analyzed the results and explored the effect of their expression levels on DNA in low methylation status. Results The expression levels of mbd2 and CD11a genes in the remission phase group ((0.21±0.040), (0.812±0.214)) and the active phase group ((0.368±0.055), (1.214±0.374)) were all significantly higher than those of the control group ((0.061±0.013), (0.413±0.103)). The expression level of CD11a gene in the active phase group was significantly higher than that in the remission phase group, with a statistically significant difference (P<0.05). Conclusions The mbd2 and CD11a genes overexpress in PBMC of SLE patients, moreover, they are closely related to the incidence of the patients.
2017, Vol. 24 
