Abstract：ObjectiveTo analyze the classification of specific allergic patients based on latent class regression analysis for early prevention of allergic diseases. Methods Using PROC LCA module of SAS software, latent class regression analysis was performed on 1124 specific allergic patients. Results Four latent class memberships and latent class probabilities were obtained. Latent class memberships were named as mold cockroach inhalation group,outdoor pollen group, dermatophagoides pteronyssinus group and comprehensive allergens group, whose probability of occurring was 0.3134, 0.3646, 0.2799 and 0.0422, respectively. Having sex as covariate, it was found that significant difference existed among four latent class memberships (P<0.05) .ConclusionsThe classification of specific allergic patients obtained through latent class regression analysis is the combination of allergens, and the association between allergens is produced by the latent class. Using latent class membership to prevent the occurrence of specific allergy is of more practical significance.
王蕊,张茂祥,李萌,刘妍妍,于磊,刘美娜. 基于潜类别回归对特异性过敏患者的分类研究[J]. 实用预防医学, 2015, 22(5): 517-519.
WANG Rui, ZHANG Mao-xiang, LI Meng, LIU Yan-yan, YU Lei, LIU Mei-na. Study on classification of specific allergic patients based on latent class regression analysis. , 2015, 22(5): 517-519.
[1] Downs S H, Marks G B, Sporik R, et al. Continued increase in the prevalence of asthma and atopy[J]. Arch Dis Child, 2001, 84(1): 20-23. [2] Hans C. Oettgen and Raif S. IgE in asthma and atopy: cellular and molecular connections[J].Geha J Clin Invest , 1999, 104(7):829-835. [3] Aalberse RC, Akkerdaas J, Ree RV. Cross‐reactivity of IgE antibodies to allergens[J]. Allergy, 2001, 56(6): 478-490. [4] 邱皓政.潜在类别模型的原理与技术[M].北京:教育科学出版社,2008． [5] Lin TH, Dayton CM. Model selection information criteria for non-nested latent class models[J]. J Educ Behav Stat, 1997, 22(3): 249-264. [6] Lanza ST, Collins LM, Lemmon DR, et al. PROC LCA: A SAS procedure for latent class analysis[J]. Structural Equation Modeling, 2007, 14(4): 671-694. [7] Johansson SG, Hourihane JO, Bousquet J, et al. A revised nomenclature for allergy: an EAACI position statement from the EAACI nomenclature task force[J]. Allergy, 2001, 56(9): 813-824. [8] Klein SL, Roberts CW. Sex Hormones and Immunity to Infection[M]. Springer Berlin Heidelberg, 2010. [9] Chen W, Mempel M, Schober W, et al. Gender difference, sex hormones, and immediate type hypersensitivity reactions[J]. Allergy, 2008, 63(11):1418-1427.
2015, Vol. 22 
