可溶性细胞间粘附分子-1在乳腺癌患者血清中表达的临床意义

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摘要目的检测乳腺癌患者血清可溶性细胞间粘附分子-1（soluble intercellular adhesion molecule-1 ,sICAM-1）表达水平,探讨血清sICAM-1与乳腺癌临床病理学指标的关系及其临床意义。方法用酶免疫吸附方法(enzyme-linked immunosorbentassay, ELISA)对61例乳腺浸润癌患者和23例乳腺良性肿瘤患者外周血中sICAM-1的水平进行定量测定,并收集患者临床资料进行统计学分析。结果 ①乳腺浸润癌组患者血清sICAM-1表达水平（1389.46+648.91ng/ml）显著高于乳腺良性肿瘤组（879.72+378.62 ng/ml）(t=4.448,P<0.001)。伴淋巴结转移组sICAM-1显著高于无淋巴结转移组(P<0.001),Ⅲ-Ⅳ 期乳腺浸润癌患者血清sICAM-1水平显著高于Ⅰ-Ⅱ 期患者（P<0.05）。②ROC曲线分析血清sICAM-1水平1186.87ng/ml是区分乳腺浸润性癌和乳腺良性肿瘤的最佳临界值;sICAM-1水平1257.38ng/ml是判断乳腺浸润性癌是否发生转移的最佳临界值。③血清sICAM-1表达水平与病理分级,年龄,肿瘤大小,乳腺癌免疫组化指标ER,PR,Ki67及HER-2均无相关性（P>0.05）。结论血清sICAM-1可作为乳腺癌的血清学观察指标,对判断肿瘤发展程度、转移状态及复发状况有较好的临床意义。

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	吴琼
	王堃
	向满林
	易斌

关键词 ：乳腺癌, 可溶性细胞间粘附分子-1, 肿瘤转移

Abstract：Objective :To detect serum soluble intercellular adhesion molecule-1 ( sICAM-1) expression level in breast cancer , explore the relationship between serum sICAM- 1 and clinical pathology indexes of breast cancer, and analyze its clinical significance. Methods :61 Patients with breast cancer and 23 patients with benign breast tumour were enrolled. Serum concentration of sICAM-1 was detected by ELISA. Results :①The average concentration of serum sICAM-1 in breast cancer was 1389.46+648.91ng/ml, and that of the benign tumor group was (879.72+378.62 ng/ml）, There was significant difference among the two groups(P<0.001), serum SICAM-1 in breast cancer with lymph node metastasis group was significantly higher than breast cancer without lymph node metastasis group, (P< 0.001), serum sICAM-1 in stage Ⅲ-Ⅳ breast carcer patients was significantly higher than stageⅠ-Ⅱ breast cancer patients(P<0.05). ②When serum sICAM-1 was set to 1186.87ng/ml , it had the best cut-off value to distinguish the breast cancer from breast benign tumor; When serum sICAM-1 was set to 1257.38ng/ml , it had the best cut-off value to judge breast cancer metastasis.③There was no significant correlation between serum sICAM-1 and pathology classification, age, tumor size, ER, PR, Ki67 and HER-2 .(P > 0.05). Conclusions :The serum sICAM-1 level can be used as a dynamic observating index of breast cancer. Measurement of sICAM-1 might be of certain clinical values in judging tumor development , metastasis and recurrence.

Key words： breast cancer. sICAM-1 metastasis.

通讯作者: 易斌,E-mail:binbinyi@hotmail.com 联系电话：0731-89753200

作者简介: 吴琼(1991-),女,硕士在读,主要从事临床生物化学检验工作。

引用本文:

吴琼, 王堃, 向满林, 易斌. 可溶性细胞间粘附分子-1在乳腺癌患者血清中表达的临床意义[J]. 实用预防医学, 2016, 23(5): 630-633. WU Qiong, WANG Kun, XIANG Man-lin, YI Bin. Expression of circulating soluble ICAM-1 in breast carcinoma and its clinical significance. , 2016, 23(5): 630-633.

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https://www.syyfyx.com/CN/ 或 https://www.syyfyx.com/CN/Y2016/V23/I5/630

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