Abstract:Manganese is a very important trace element in the body, but in the occupational environment, some workers exposed to manganese may occur acute or chronic manganese poisoning, irreversible mental and extrapyramidal nerve damage like the clinical manifestations of Parkinson syndrome. The mechanism of manganese-induced neurotoxicity is still not clear. The present advances in the neurological mechanism of manganese-induced dopamine transport disorder, mitochondrial dysfunction, oxidative stress, neurotransmitter transmission and inflammatory reaction are summarized in this article.
[1] Paris I, Segura-Aguilar J. The role of metal ions in dopaminergic neuron degeneration in parkinsonism and Parkinson’s disease[J]. Cheminform, 2011, 42(32):365-374. [2] Tomás R, Guilarte. Manganese and Parkinson's Disease: A critical review and new findings[J]. Environ Health Persp, 2010, 16(11):4519-4566. [3] Roth JA, Li Z, Sridhar S, et al. The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and dat transfected hek cells[J]. Neurotoxicology, 2013, 35(3):121-128. [4] Segura-Aguilar J, Paris I, Muoz P, et al. Protective and toxic roles of dopamine in Parkinson's disease[J]. J Neurochem, 2014, 129(6): 898-915. [5] Aschner M, Aschner J L, Maitre N L. Manganese neurotoxicity: from worms to neonates[J]. Neurotoxicol Teratol, 2013, 37(5):78. [6] Sriram K, Lin GX, Jefferson AM, et al. Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes[J]. Arch Toxicol, 2010, 84(7): 521-540. [7] Racette BA, Aschner M, Guilarte TR, et al. Pathophysiology of manganese-associated neurotoxicity[J]. Neurotoxicology, 2012, 33(4):881-886. [8] Benedetto A, Au C, Avila DS, et al. Extracellular dopamine potentiates Mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in caenorhabditiselegans[J]. PLoS Genet, 2010, 6(8):182-188. [9] Chakraborty S, Aschner M. Altered manganese homeostasis: implications for BLI-3-dependent dopaminergic neurodegeneration and SKN-1 protection in C. elegans[J]. J Trace Elem Med Bio, 2012, 26:183-187. [10] Sidoryk-Wegrzynowicz M, Lee E, Albrecht J, et al. Manganese disrupts astrocyte glutamine transporter expression and function[J]. J Neurochem, 2009, 110(3):822-830. [11] Farina M, Avila DS, Rocha JBTD, et al. Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury[J]. Neurochem Int, 2013, 62(5):575-594. [12] Sidoryk-Wegrzynowicz M, Lee E, Ni MW, et al. Disruption of astrocytic glutamine turnover by manganese is mediated by the protein kinase C pathway[J]. Glia, 2011, 59(11):1732-1743. [13] Roth JA, Sridhar S, Singleton ST. Effect of glutamate and riluzole on manganese-induced apoptotic cell signaling in neuronally differentiated mouse P19 Cells[J]. Neurochem Int, 2012, 61(1):25-33. [14] Fordahl SC, Anderson JG, Cooney PT, et al. Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats[J]. Neurotoxicology, 2010, 31(6): 639-646. [15] 邓宇, 王飞, 徐斌, 等. 锰对小鼠黑质多巴胺转运体和受体表达影响的研究[J]. 实用预防医学, 2014, 21(3): 257-260. [16] Cordova FM, Aguiar Jr AS, Peres TV, et al. Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox [J]. Arch Toxicol, 2013, 87(7): 1231-1244. [17] Yoon H, Kim DS, Lee GH, et al. Apoptosis induced by manganese on neuronal SK-N-MC cell line: endoplasmic reticulum (ER) stress and mitochondria dysfunction[J]. Environ Health Toxicol, 2011, 26:e2011017. [18] Stephenson AP, Schneider JA, Nelson BC, et al. Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: attenuation of thymine base lesions by glutathione and N-acetylcysteine[J]. Toxicol Lett, 2013, 218(3):299-307. [19] Martinez-Finley EJ, Gavin CE, Aschner M, et al. Manganese neurotoxicity and the role of reactive oxygen species[J]. Free Radic Biol Med, 2013, 62(9):65-75. [20] Filipov NM, Dodd CA. Role of glial cells in manganese neurotoxicity[J]. J Appl Toxicol, 2012, 32(5):310-317. [21] 任改艳, 孙阿宁, 张晶晶, 等. NF-κB在细胞凋亡中调节作用的研究进展[J]. 中国药理学与毒理学杂志, 2015, 29(2): 323-327. [22] Corona JC, Duchen MR. PPARγ and PGC-1α as therapeutic targets in Parkinson’s[J]. Neurochem Res, 2014, 40(2): 308-316.