Abstract：Parkinson’s disease (PD) is a neurodegenerative disease commonly seen in middle-aged and elderly people, with chronic progression and no cure. Parkinson's disease has a long incubation period from actual onset to clinical diagnosis. For a long time, the best strategy for this chronic and protracted disease with unknown prodromal stage is to prevent the occurrence of this disease. This article reviews the known and feasible prevention measures related to Parkinson’s disease at home and abroad from two aspects of dietary pattern and physical exercise, makes a brief report on the research status of relatively high-risk population and summarizes some low-risk, potentially high-benefit lifestyle improvement suggestions so as to reduce the personal pain and social burden caused by Parkinson’s disease as much as possible.
班昕, 刘玉莹, 刘雪莹, 王勋, 代大伟, 张黎明. 饮食模式与体育锻炼对帕金森病的预防作用及高风险人群的研究现状[J]. 实用预防医学, 2022, 29(8): 1020-1024.
BAN Xin, LIU Yu-ying, LIU Xue-ying, WANG Xun, DAI Da-wei, ZHANG Li-ming. Preventive effect of diet pattern and physical exercise on Parkinson’s diseaseand research status of related high-risk population. , 2022, 29(8): 1020-1024.
[1] GBD 2016 Parkinson' Disease Collaborators.Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016[J]. Lancet Neurol, 2018,17(11):939-953. [2] Dorsey ER, Bloem BR. The Parkinson pandemic-a call to action[J]. JAMA Neurol, 2018,75(1):9-10. [3] Li G, Ma J, Cui S, et al. Parkinson's disease in China: a forty-year growing track of bedside work[J]. Transl Neurodegener, 2019,8:22. [4] Poortvliet PC, O'Maley K, Silburn PA, et al. Perspective: current pitfalls in the search for future treatments and prevention of Parkinson's disease[J]. Front Neurol, 2020,11:686. [5] Braak H,de Vos RA,Bohl J,et al. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology[J]. Neurosci Lett, 2006,396(1):67-72. [6] Travagli RA, Browning KN, Camilleri M. Parkinson disease and the gut: new insights into pathogenesis and clinical relevance[J]. Nat Rev Gastroenterol Hepatol, 2020,17(11):673-685. [7] Jackson A,Forsyth CB,Shaikh M,et al. Diet in Parkinson's disease: critical role for the microbiome[J]. Front Neurol, 2019,10:1245. [8] Lee HS, Lobbestael E, Vermeire S, et al. Inflammatory bowel disease and Parkinson's disease: common pathophysiological links[J]. Gut, 2021,70(2):408-417. [9] Cunnane SC, Trushina E, Morland C, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing[J]. Nat Rev Drug Discov, 2020,19(9):609-633. [10] Tosti V, Bertozzi B, Fontana L. Health benefits of the Mediterranean diet: metabolic and molecular mechanisms[J]. J Gerontol A Biol Sci Med Sci, 2018,73(3):318-326. [11] Maraki MI, Yannakoulia M, Stamelou M, et al. Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease[J]. Mov Disord, 2019,34(1):48-57. [12] Molsberry S,Bjornevik K,Hughes KC,et al. Diet pattern and prodromal features of Parkinson disease[J]. Neurology, 2020,95(15):e2095-e2108. [13] Mentis AA, Dardiotis E, Efthymiou V, et al. Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews[J]. BMC Med, 2021,19(1):6. [14] Barbaresko J, Lellmann AW, Schmidt A, et al. Dietary factors and neurodegenerative disorders: an umbrella review of meta-analyses of prospective studies[J]. Adv Nutr, 2020,11(5):1161-1173. [15] Yin W, Löf M, Pedersen NL, et al. Mediterranean dietary pattern at middle age and risk of Parkinson's disease: a Swedish cohort study[J]. Mov Disord, 2021,36(1):255-260. [16] Paknahad Z, Sheklabadi E, Derakhshan Y, et al. The effect of the Mediterranean diet on cognitive function in patients with Parkinson's disease: a randomized clinical controlled trial[J]. Complement Ther Med, 2020,50:102366. [17] Sánchez-Sánchez ML, García-Vigara A, Hidalgo-Mora JJ, et al. Mediterranean diet and health: a systematic review of epidemiological studies and intervention trials[J]. Maturitas, 2020,136:25-37. [18] Włodarek D. Role of ketogenic diets in neurodegenerative diseases (Alzheimer's disease and Parkinson's disease)[J]. Nutrients, 2019,11(1):169. [19] Phillips M,Murtagh D,Gilbertson LJ,et al. Low-fat versus ketogenic diet in Parkinson's disease: a pilot randomized controlled trial[J]. Mov Disord, 2018,33(8):1306-1314. [20] Koyuncu H,Fidan V,Toktas H,et al. Effect of ketogenic diet versus regular diet on voice quality of patients with Parkinson's disease[J]. Acta Neurol Belg, 2021,121:1729-1732. [21] Veyrat-Durebex C,Reynier P,Procaccio V,et al. How can a ketogenic diet improve motor function?[J]. Front Mol Neurosci, 2018,11:15. [22] Jensen NJ, Wodschow HZ, Nilsson M, et al. Effects of ketone bodies on brain metabolism and function in neurodegenerative diseases[J]. Int J Mol Sci, 2020,21(22):8767. [23] Koh S, Dupuis N, Auvin S. Ketogenic diet and neuroinflammation[J]. Epilepsy Res, 2020,167:106454. [24] McDonald T,Cervenka MC. Lessons learned from recent clinical trials of ketogenic diet therapies in adults[J]. Curr Opin Clin Nutr Metab Care, 2019,22(6):418-424. [25] Godos J,Tieri M,Ghelfi F,et al. Dairy foods and health: an umbrella review of observational studies[J]. Int J Food Sci Nutr, 2020,71(2):138-151. [26] Boulos C,Yaghi N,El Hayeck R,et al. Nutritional risk factors, microbiota and Parkinson's disease: what is the current evidence?[J]. Nutrients, 2019,11(8):1896. [27] Schepici G, Silvestro S, Bramanti P, et al. Caffeine: an overview of its beneficial effects in experimental models and clinical trials of Parkinson's disease[J]. Int J Mol Sci, 2020,21(13):4766. [28] Bakshi R,Macklin EA,Hung AY,et al. Associations of lower caffeine intake and plasma urate levels with idiopathic Parkinson's disease in the Harvard Biomarkers Study[J]. J Parkinsons Dis, 2020,10(2):505-510. [29] Peng B, Yang Q, B Joshi R, et al. Role of alcohol drinking in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis[J]. Int J Mol Sci, 2020,21(7):2316. [30] Cammisuli DM, Bonuccelli U, Daniele S, et al. Aerobic exercise and healthy nutrition as neuroprotective agents for brain health in patients with Parkinson's disease: a critical review of the literature[J]. Antioxidants (Basel), 2020,9(5):380. [31] Fan B, Jabeen R, Bo B, et al. What and how can physical activity prevention function on Parkinson's disease?[J]. Oxid Med Cell Longev, 2020,2020:4293071. [32] Olsson TT,Svensson M,Hallmarker U,et al. Delayed clinical manifestation of Parkinson's disease among physically active: do participants in a long-distance ski race have a motor reserve?[J]. J Parkinsons Dis, 2020,10(1):267-274. [33] Hughes KC,Gao X,Molsberry S,et al. Physical activity and prodromal features of Parkinson disease[J]. Neurology, 2019,93(23):e2157-e2169. [34] Schootemeijer S,van der Kolk NM,Bloem BR,et al. Current perspectives on aerobic exercise in people with Parkinson's disease[J]. Neurotherapeutics, 2020,17(4):1418-1433. [35] Vieira de Moraes Filho A,Chaves SN,Martins WR,et al. Progressive resistance training improves bradykinesia, motor symptoms and functional performance in patients with Parkinson's disease[J]. Clin Interv Aging, 2020,15:87-95. [36] Feng YS, Yang SD, Tan ZX, et al. The benefits and mechanisms of exercise training for Parkinson's disease[J]. Life Sci, 2020,245:117345. [37] Zhu M, Zhang Y, Pan J, et al. Effect of simplified Tai Chi exercise on relieving symptoms of patients with mild to moderate Parkinson's disease[J]. J Sports Med Phys Fitness, 2020,60(2):282-288. [38] Singh R, Pattisapu A, Emery MS. US physical activity guidelines: current state, impact and future directions[J]. Trends Cardiovasc Med, 2020,30(7):407-412. [39] Heinzel S,Berg D,Gasser T,et al. Update of the MDS research criteria for prodromal Parkinson's disease[J]. Mov Disord, 2019,34(10):1464-1470. [40] 中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍病专业委员会.帕金森病前驱期诊断研究标准中国专家共识[J]. 中华老年医学杂志,2019,38(8):825-831. [41] Galbiati A, Verga L, Giora E, et al. The risk of neurodegeneration in REM sleep behavior disorder: a systematic review and meta-analysis of longitudinal studies[J]. Sleep Med Rev,2019,43:37-46. [42] Nyein H, Bariya M, Tran B, et al. A wearable patch for continuous analysis of thermoregulatory sweat at rest[J]. Nat Commun, 2021,12(1):1823. [43] Kasdagli MI, Katsouyanni K, Dimakopoulou K, et al. Air pollution and Parkinson's disease: a systematic review and meta-analysis up to 2018[J]. Int J Hyg Environ Health, 2019,222(3):402-409. [44] Wang Y,Liu Y,Yan H. Effect of long-term particulate matter exposure on Parkinson's risk[J]. Environ Geochem Health, 2020,42(7):2265-2275. [45] Cariccio VL, Samà A, Bramanti P, et al. Mercury involvement in neuronal damage and in neurodegenerative diseases[J]. Biol Trace Elem Res, 2019,187(2):341-356. [46] Martins AC Jr, Morcillo P, Ijomone OM, et al. New insights on the role of manganese in Alzheimer's disease and Parkinson's disease[J]. Int J Environ Res Public Health, 2019,16(19):3546. [47] Ryu HJ, Park J, Choi M, et al. Parkinson's disease and skin cancer risk: a nationwide population-based cohort study in Korea[J] .2020,34(12):2775-2780. [48] Laurence M, Benito-León J, Calon F. Malassezia and Parkinson's disease[J]. Front Neurol, 2019,10:758. [49] van Wamelen DJ,Leta V,Podlewska AM,et al. Exploring hyperhidrosis and related thermoregulatory symptoms as a possible clinical identifier for the dysautonomic subtype of Parkinson's disease[J]. J Neurol, 2019,266(7):1736-1742. [50] Papakonstantinou E, Limberg MM, Gehring M, et al. Neurological disorders are associated with bullous pemphigoid[J]. J Eur Acad Dermatol Venereol, 2019,33(5):925-929. [51] Wingo TS. Parkinson disease risk in patients with rosacea[J]. JAMA Neurol, 2016,73(5):501-502. [52] Mathieu RJ,Guido N,Ibler E,et al. Rosacea and subsequent diagnosis for Parkinson's disease: a large, urban, single center, US patient population retrospective study[J]. J Eur Acad Dermatol Venereol, 2018,32(4):e141-e144. [53] Villumsen M, Aznar S, Pakkenberg B, et al. Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish Nationwide Cohort Study 1977-2014[J].Gut, 2019,68(1):18-24. [54] Weimers P,Halfvarson J,Sachs MC,et al. Inflammatory bowel disease and Parkinson's disease: a Nationwide Swedish Cohort Study[J]. Inflamm Bowel Dis, 2019,25(1):111-123. [55] Park S,Kim J,Chun J,et al. Patients with inflammatory bowel disease are at an increased risk of Parkinson's disease: a south Korean nationwide population-based study[J]. J Clin Med, 2019,8(8):1191. [56] Wan QY, Zhao R, Wu XT. Older patients with IBD might have higher risk of Parkinson's disease[J]. Gut, 2020,69(1):193-194. [57] Chen SF, Yang YC, Hsu CY, et al. Risk of Parkinson's disease in patients with hypothyroidism: a nationwide population-based cohort study[J]. Parkinsonism Relat Disord, 2020,74:28-32. [58] White DL, Kunik ME, Yu H, et al. Post-traumatic stress disorder is associated with further increased Parkinson's disease risk in veterans with traumatic brain injury[J]. Ann Neurol, 2020,88(1):33-41. [59] Singh A,Tripathi P,Singh S. Neuroinflammatory responses in Parkinson's disease: relevance of Ibuprofen in therapeutics[J]. Inflammopharmacology, 2021,29(1):5-14. [60] Liu G,Sterling NW,Kong L,et al. Statins may facilitate Parkinson's disease: insight gained from a large, national claims database[J]. Mov Disord, 2017,32(6):913-917. [61] Hopfner F,Höglinger GU,Kuhlenbäumer G,et al. β-adrenoreceptors and the risk of Parkinson's disease[J]. Lancet Neurol, 2020,19(3):247-254. [62] Cortese M,Riise T,Engeland A,et al. Urate and the risk of Parkinson's disease in men and women[J]. Parkinsonism Relat Disord, 2018,52:76-82. [63] Piercy KL, Troiano RP, Ballard RM, et al. The physical activity guidelines for Americans[J]. JAMA, 2018,320(19):2020-2028. [64] Murray A, Foster C, Stamatakis E. Let's share, help deliver and sustain the WHO global action plan on physical activity[J]. Br J Sports Med, 2019,53(13):794-796.
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