Abstract：Objective To study the prophylactic effect of Jiangzhi dropping pills on experimental hyperlipidemia in rats. Methods Sixty healthy male SD rats were randomly divided into 6 groups: normal control group, model control group, positive control group (lovastatin group), as well as low-, middle- and high-dose groups of Jiangzhi dropping pills. The rats in the normal control group were fed with normal diet, while the rats in the other groups were fed with high fat diet. Besides, the rats in the positive control group was orally administrated with lovastatin at a dose of 0.002 g/kg once a day, and the low-, middle- and high-dose groups of Jiangzhi dropping pills were orally administrated with Jiangzhi dropping pills at the doses of 0.13 g/kg, 0.25 g/kg and 0.50 g/kg respectively once a day. All the rats had free access to water. Their weight was measured every 7 days. 40 days later, all the rats were fasted for 12 hours and then sacrificed. Blood samples were collected from the ophthalmic venous plexus to determine serum total cholesterol (TC), serum triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (APOA1) and apolipoprotein B (APOB). Results No statistically significant differences were found in the TC, TG, LDL and HDL levels among all the groups before treatment (P>0.05). After treatment, the TC, TG and LDL levels of the model group were significantly increased as compared with those of the normal control group (P<0.01), while HDL was significantly decreased (P<0.05), indicating the hyperlipidemia model had been successfully established. As compared with the model group, the body weight of the rats in the middle- and high-dose groups of Jiangzhi dropping pills was significantly decreased (P<0.05). The TC and TG levels in the high-dose group of Jiangzhi dropping pills declined differently (P<0.05), while the APOA1 level was elevated (P<0.05). The APOB level in the middle- and high-dose groups was decreased to different extents (P<0.05, P<0.01). Conclusions Jiangzhi dropping pills can lower blood lipid in hyperlipidemic rats.
2016, Vol. 23 
