Epidemiological survey and genetic sequence analysis of a human case infected with avian influenza A (H9N2) virus in Loudi City
YANG Qingting1, HUANG Chaoyang2, YU Biao3, ZENG Ziyan1, YANG Xueyan1, LIU Shuguang1, ZHU Pan1, ZHOU Dan1, YANG Gang1
1. Loudi Municipal Center for Disease Control and Prevention, Loudi, Hunan 417000, China; 2. Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan 410153, China; 3. Xinhua County Center for Disease Control and Prevention, Xinhua, Hunan 417600, China
Abstract：Objective To conduct an epidemiological survey and genetic sequence analysis on a case of human infection with avian influenza A (H9N2) virus in Loudi City so as to provide a basis for scientific prevention and control of avian influenza in future. Methods On February 10, 2023, an epidemiological investigation was conducted among close and secondary close contacts of a patient diagnosed with avian influenza A (H9N2) virus infection as well as the nearby live poultry market in Loudi City, Hunan Province.In addition, the patient's as well as close and secondary close contacts' throat swab samples were collected for genetic sequence analysis. Results All the subjects detected presented negative nucleic acid testing results except the patient. Testing of chicken blood samples and environmental samples from the patient's residence and its neighborhood also showed negative results for avian influenza viruses, but H9N2 was detected in samples collected from the nearby live poultry market. Genetic sequence analysis revealed that the hemagglutinin (HA) gene sequence of the strains detected and H9N2 strains previously obtained from human infection in mainland China displayed homologies ranging from 83.6% to 98.5%, which were closest withON856627/Fujiansiming/2021(H9N2)Human/HA,with the homology being 98.5%. The neuraminidase (NA) gene sequence of the strains detected and H9N2 strains previously obtained from human infection in mainland China displayed homologies ranging from 83.3% to 95.5%, which were closest with MT875139/A Szuhou/2019(H9N2)Human/NA, with the homology being 95.5%. Conclusion The patient's infection with avian influenza A (H9N2) virus is closely related to the existence of avian influenza A virus in the local live poultry market. In future, routine surveillance for influenza-like illnesses should be improved by increasing the sample size and sampling frequency.
杨青廷, 黄超洋, 余彪, 曾紫嫣, 杨雪艳, 刘曙光, 朱攀, 周丹, 杨纲. 娄底市1例人感染H9N2禽流感病毒流行病学调查与基因序列分析[J]. 实用预防医学, 2024, 31(2): 172-175.
YANG Qingting, HUANG Chaoyang, YU Biao, ZENG Ziyan, YANG Xueyan, LIU Shuguang, ZHU Pan, ZHOU Dan, YANG Gang. Epidemiological survey and genetic sequence analysis of a human case infected with avian influenza A (H9N2) virus in Loudi City. , 2024, 31(2): 172-175.
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2024, Vol. 31 
