Abstract：Objective To explore the role of lymphotoxin-like inducible protein that competes with glycoprotein D for herpesvirus entry on T cells (LIGHT) costimulatory pathway in Chlamydia psittaci (Cps) respiratory tract infection. Methods Wild type(WT)and LIGHT knock out (KO) C57BL/6J mice were inoculated intranasally with 4.5×105 IFU Cps. The food intake,activities,body weight changes and survival rates were recorded every day.The mice were sacrificed on days 4,9 and 14 post-infection respectively, and then lung tissues were cllolected. Live Cps load and pathological changes in the lung were detected. Results LIGHT KO mice showed more serious respiratory tract symptoms and lower survival rate than WT mice. They developed much more severe pathological changes, and had higer Cps load and delayed Cps clearance in the lung homogenate. Conclusions The deficiency of LIGHT gene can aggravate Chlamydia psittaci respiratory tract infection.
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2017, Vol. 24 
