Nested case-control study of diabetic retinopathy in patients with type 2 diabetes mellitus in Yanji Community of Shanghai
LIU Yu1,2, BIAN Xin3, FENG Jian-xiu4, WANG Jia-hong5
1. Yanji Community Health Service Center of Yangpu District, Shanghai 200093, China; 2. School of Medicine, Tongji University, Shanghai 200092, China; 3. Kongjiang Hospital of Yangpu District, Shanghai 200093, China; 4. Yangpu District Eye Disease Prevention and Control Center, Shanghai 200093, China; 5. Yangpu Hospital Affiliated to Tongji University, Shanghai 200090, China
Abstract：Objective To analyze the incidence rate of diabetic retinopathy (DR) and its related influencing factors in patients with type 2 diabetes mellitus (T2DM) in Yanji Community of Shanghai, and to provide evidence for its early prevention and intervention. Methods Five hundred and ninety-seven patients without diabetic retinopathy in the baseline survey in July 2017 were selected as the research subjects. After a follow-up of 2 years, ocular fundus examination was performed again in August 2019 and the incidence rate of DR inthe T2DMpatientswas calculated. A 1∶2 matched nested case-control study was carried out to calculate the OR value and 95% confidence interval of each single factor. Cox regression model was used to fitcompatible logistic regression model, and the factors influencing DR were explored. Results The 2-year cumulative incidence rate of DR in the patients with T2DM in Yanji Community of Shanghai was 21.94%, of which 93 patients suffered from mild non-proliferative diabetic retinopathy (NPDR) (including 44 males and 49 females) and 38 moderate NPDR (including 20 males and 18 females). Multiple factor analysis showed that drinking (OR=2.839, 95%CI:1.025-7.859), family history of diabetes (OR=3.867, 95%CI:1.826-8.188), fasting blood glucose (OR=3.648, 95%CI:1.668-7.978), glycated hemoglobin A1C (HbA1C) (OR=6.066, 95%CIP:2.815-13.071), blood pressure (OR=2.076, 95%CI:1.097-3.929) and history of atherosclerotic cardiovascular disease (OR=2.415, 95%CI:1.208-4.827) were factors influencing the occurrence of DR. Conclusion The 2-year cumulative incidence rate of DR in the patients with T2DM in Yanji Community of Shanghai was 21.94%. Drinking, blood pressure, family history of diabetes, fasting blood glucose, HbA1c and history of atherosclerotic cardiovascular disease were factors affecting the incidence of DR.
刘宇, 卞鑫, 冯建秀, 王加红. 上海市延吉社区2型糖尿病患者糖尿病视网膜病变巢式病例对照研究[J]. 实用预防医学, 2021, 28(6): 679-683.
LIU Yu, BIAN Xin, FENG Jian-xiu, WANG Jia-hong. Nested case-control study of diabetic retinopathy in patients with type 2 diabetes mellitus in Yanji Community of Shanghai. , 2021, 28(6): 679-683.
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2021, Vol. 28 
