Abstract：Objective To detect the levels of plasma fibrinogen (FIB) and angiopoietin-2 (ANG-2) in patients with colorectal carcinoma, and to explore their value in the diagnosis and treatment of colorectal carcinoma. Methods Automatic coagulation analyzer ACTTOP500was used to detect plasma FIB in 108 patients with colorectal carcinoma and 60 health examinees. And ELISA was employed for testing plasma ANG-2 in the two groups. Results The levels of plasma FIB and ANG-2 were significantly higher in the patients with colorectal carcinoma ((5.08±1.14)g/L, (3.15±0.58)g/L) than in the healthy control group ((2.78±0.32)g/L, (1.03±0.21)g/L), with statistically significant differences (both P<0.01). The levels of plasma FIB and ANG-2 were increased with the progression of clinical stages (both P<0.01), showing a positive correlation between them (r=0.97, P=0.0136). Conclusions Both of FIB and ANG-2 participate in the incidence and development of colorectal cancinoma. Combined detection oflevels of plasma FIB and ANG-2 has important clinical value in the early diagnosis, staging and prognosis judgment of colorectal carcinoma.
2017, Vol. 24 
