Monitoring results of rotavirus diarrhea in infants aged 0-24 months in a county of Hebei province
ZHANG Jun1,2, ZHANG Yan-hong3, GAO Zhao2, LIU Ying-ying2, LI Qing-liang4, WU Zhi-wei2, SU Tong2, YANG Zhi-qin3, ZHAO Yu-liang2
1. School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063000, China; 2. Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang, Hebei 050021, China; 3. Zhengding County Center for Disease Control and Prevention, Shijiazhuang, Hebei 050021, China; 4. Wuhan Biological Products Research Institute Co., Ltd., Wuhan, Hubei 430207, China
Abstract：Objective To understand the prevalence of rotavirus diarrhea in a county of Hebei province, and to provide data support for designing clinical trials of rotavirus vaccines. Methods All infants aged 0-24 months resided in 7 towns of Zhengding county, Hebei province served as the monitoring subjects. Active monitoring was performed from December 2016 to March 2017. Stool samples of diarrhea infants were collected, rotavirus antigen was detected, and strain typing was conducted in samples positive for antigen. Results A total of 2,017 infants aged 0-24 months were monitored, the incidence rate of diarrhea was 16.26% (328/2,017), and the detection rate of rotavirus was 14.41% (47/326). The incidence rate of rotavirus diarrhea was 2.33% (47/2,017), and the incidence rate of the group aged 18-20 months was the highest (5.20%), showing an upward trend with the increasing age (χ2tendency=9.948, P=0.002). The incidence rates of rotavirus diarrhea in the months monitored were 1.26%, 0.54%, 0.25% and 0.25%, respectively, with statistically significant differences (χ2tendency=24.684, P<0.001). Among the 47 positive samples, G2 was the most common in G serotype samples (74.46%), P[4] the most common in P genotype samples (72.34%), and G2P[4] the most common in G/P samples (72.34%). The rate of moderate and severe diarrhea induced by rotavirus was 23.40%, while that induced by other causes was 11.30%, showing a statistically significant difference (χ2=5.52, P=0.019). Conclusions The incidence rate of rotavirus diarrhea in infants under the age of 24 months in the county monitored showed an overall upward trend with the increasing age, diarrhea caused by rotavirus was more serious than that induced by other causes, and G2P[4] was the main epidemic strain.
2020, Vol. 27 
