Abstract：Objective To explore the relation between early renal damage and ventricular remodeling in patients with type 2 diabetes mellitus. Methods One hundred and one patients with type 2 diabetes mellitus hospitalized in Sichuan Science City Hospital from February 2015 to August 2016 were divided into two groups according to their 24 h urinary microalbumin (UMA) level, the diabetes mellitus group (UMA < 30 mg/24 h, n=67) and the microalbuminuria group (UMA 30-300mg/24h, n=34). And 50 health examinees were simultaneously randomly selected as the control group. The left ventricular end-diastolic diameter (LVDD), interventricular septal end-diastolic thickness (IVS) and left ventricular posterior wall end diastolic thickness (LVPW) were measured by the color Doppler ultrasonography. The left ventricular mass (LVM), left ventricular mass index (LVMI) and relative ventricular wall thickness (RWT) were calculated. At the same time, the laboratory testing indexes of blood and urine were recorded. Multiple linear regression analysis was used to analyze the factors affecting ventricular remodeling. Results LVPW, LVM and LVMI of the diabetes mellitus group and the microalbuminuria group as well as RWT of the microalbuminuria group were all higher than those of the control group (all P<0.05); moreover, LVPW, LVM, LVMI and RWT of the microalbuminuria group were all higher than those of the diabetes mellitus group, showing statistically significant differences (all P<0.05). Serum triglyceride (TG), fibrinogen (Fg), uric acid (UA), fasting blood glucose (FPG) and 2h postprandial glucose (2hPG) of the diabetes mellitus group and the microalbuminuria group as well as UMA of the microalbuminuria group were all higher than those of the control group (all P<0.05); moreover, TG, Fg, FPG, 2hPG and UMA of the microalbuminuria group were all higher than those of the diabetes mellitus group, with statistically significant differences (all P<0.05). Multiple linear regression analysis showed that FPG, 2hPG, UMA and age were all the significant factors affecting the increase of LVMI (all P<0.05). Conclusions The type 2 diabetes mellitus patients with early renal dysfunction is prone to ventricular remodeling; moreover, venerable age and elevated UMA are the independent risk factors. Therefore, special attention should be paid to the high-risk population in clinical practice, and targeted intervention measures should be taken.
曹丽萍, 赵国忠, 何敏, 陈晨, 丁云蕾. 2型糖尿病早期肾损害与心室重构的关系研究[J]. 实用预防医学, 2017, 24(5): 544-547.
CAO Li-ping, ZHAO Guo-zhong, HE Min, CHEN Chen, DING Yun-lei. Relationship between early renal damage and ventricular remodeling in patients with type 2 diabetes mellitus. , 2017, 24(5): 544-547.
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2017, Vol. 24 
