Abstract：Objective To analyze the clinical and epidemiological features of human bocavirus (HBoV) infection among 4,232 children with acute respiratory tract infection (ARTI) in Wuhan region. Methods Nasopharyngeal aspirate (NPA) samples were collected from 4,232 children aged 7 years and below and confirmed with ARTI from January 1st, 2014 to December 31st, 2015. Real-time polymerase chain reaction (RT-PCR) assay was used to detect the HboV, and the mixed infection was examined through simultaneously determining the other 7 respiratory viruses (including Inf-A, Inf-B, RSV, ADV, PIV-I, PIV-II and PIV-III). Epidemiological characteristics of HboV infection were analyzed based on the screening results and clinical information of the corresponding cases. Results Among the 4,232 NPA specimens, the positive detection rate of HBoV was 1.23% (52/4,232), and the rate was found to be the highest in children aged 1-<3 years (2.81%, 24/854). The detection rates of HBoV infection in the spring (3.05%), summer (0.60%), fall (0.52%) and winter (0.24%) showed statistically significant differences (χ2=36.784,P=0.002), of which the rate in the spring was the highest. The co-infection rate of HboV and other respiratory viruses was 69.23% (36/52). The positive detection rate of HBoV in children with bronchial pneumonia was the highest(51.92%). Conclusions HBoV was one of the main pathogens in children with ARTI in Wuhan region during 2014-2015, which was more prevalent in children aged 1-<3 years. The co-infection rate of HBoV and other respiratory viruses was high; moreover, HBoV infection commonly occurred in spring.
王瑢,丁淑贤,倪文昌,鲍星星,边俊梅. 2014-2015年武汉地区4 232例儿童呼吸道人类博卡病毒感染流行病学特征[J]. 实用预防医学, 2018, 25(4): 429-432.
WANG Rong, DING Shu-xian, NI Wen-chang, BAO Xing-xing, BIAN Jun-mei. Epidemiological characteristics of human bocavirus infection in 4,232 children with respiratory tract infection in Wuhan region, 2014- 2015. , 2018, 25(4): 429-432.
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2018, Vol. 25 
