Dynamic changes and relationship study on plasma D-dimer, T lymphocyte subsets and C- reactive protein in pregnant women with pregnancy-induced hypertension during perinatal period
Zhong Xiaohong
Clinical laboratory of PLA’s 163 hospital, Changsha Hunan 410003
Abstract：Objective:To explorer the dynamic changes and correlation on plasma D-dimer(D-D), T lymphocyte subsets and C- reactive protein(CRP) in pregnant women with pregnancy-induced hypertension (PIH) during perinatal period. Methods:120 pregnant women with PIH were selected as PIH group, and 60 healthy pregnant women were selected as control group. Plasma D-D, CD3+, CD4+ and CD8+T cell lymphocyte subsets and CRP level were detected before and 3d after delivery, and correlation was analyzed between above indicators. Results:There was no statistical difference on plasma D-D, T lymphocyte subsets and CRP before and 3d after delivery in control group (P>0.05). Before delivery, PIH group’s plasma D-D, CRP and CD4+/CD8+ were all higher than those in control group(P<0.01or P<0.05). 3d after delivery, PIH group’s plasma D-D and CRP were both decreased(P<0.05), and CD4+/CD8+ were increased(P<0.05),yet they were all higher than those in control group(P<0.05). Above indicators in PIH group were analyzed by Pearson correlation, and showed that they were both positive correlation with each other(r D-D-CRP=0.62,r D-D- CD4+/CD8+ =0.47,r CRP-CD4+/CD8+ =0.52,P<0.01). Conclusion:Plasma D-D, T lymphocyte subsets and CRP in pregnant women with PIH during perinatal period is high, and is higher than healthy pregnant women before and after delivery, and there is positive correlation with each other among the indicators, so it suggests PIH’s occurrence and development is complex process involving multiple factors, including the pathological process of immune, inflammatory reaction, vascular endothelial cells’ injury, coagulation / fibrinolytic system imbalance and so on, and it maybe synchronized and is interactional process.
钟晓红. 妊娠高血压综合征孕妇围产期血浆D-二聚体、T淋巴细胞亚群与C-反应蛋白的动态变化及其关系研究[J]. 实用预防医学, 2015, 22(7): 866-868.
Zhong Xiaohong. Dynamic changes and relationship study on plasma D-dimer, T lymphocyte subsets and C- reactive protein in pregnant women with pregnancy-induced hypertension during perinatal period. , 2015, 22(7): 866-868.
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2015, Vol. 22 
