Abstract：Tuberculosis , which is one of the major infectious disease ,be regarded as a threaten to human's health. Rifampicin and isoniazid is the most widely used anti tuberculosis drugs, but due to improper used, resistant strains are increasing, which bring huge challenge to the treatment of tuberculosis .The study on the molecular mechanism of drug resistance of Mycobacterium tuberculosis is mainly concentrated in the drug targets and associated mutations in the gene. The molecular mechanism of isoniazid resistance is very complex, involving Kat G, INH A, KAS A, oxy R, ndh and other genes ; However rifampin is mainly because of rpo B gene mutation. This review will present the gene mutation of drug resistance of rifampin and isoniazid in recent years.
邓叶华,向延根,马小华,范任华,石国民,喻容. 结核分枝杆菌耐利福平和异烟肼分子机制的研究进展[J]. 实用预防医学, 2015, 22(9): 1148-1151.
DENG ye-hua, XIANG yan-gen, MA xiao-hua, FAN ren-hua, SHI guo-min, YU rong. Research progress in molecular mechanisms of rifampicin and isoniazid resistance in Mycobacterium tuberculosis. , 2015, 22(9): 1148-1151.
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2015, Vol. 22 
