Abstract：Objective To develop a method on the determination of dichloroacetic acid(DCAA) and trichloroacetic acid(TCAA) in drinking water by ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS). Methods Water samples were filtered by 0.2μm membrance, then seperated on the column of HSS T3 with a gradient elution using acetonitrile/0.1% formic acid water ,detected by electrospray ionization tandem mass spectrometry in negative mode using multiple reaction monitoring. Results The linear range of DCAA and TCAA was 5.0~100.0μg/L.The correlation coefficient was above 0.999. The limit of detection and quantitation were 0.5μg/L and 1.5μg/L, respectively. At the fortified concentrations of 10.0,20.0 and 50.0μg/L for blank drinking water, the average recoveries of DCAA and TCAA were 88.9%~113.7%,with the relative standard deviation below 6.0%. Conclusions This method is simple,fast,sensitive and accurate.It is suitable for the rapid determination of DCAA and TCAA in drinking water.
李莉, 刘斌, 赵慧琴. 超高效液相色谱-串联质谱法测定生活饮用水中二氯乙酸和三氯乙酸[J]. 实用预防医学, 2016, 23(2): 229-231.
LI Li, LIU Bin, ZHAO Hui-qin. Determination of Dichloroacetic Acid and Trichloroacetic Acid in Drinking Water by UPLC-MS/MS. , 2016, 23(2): 229-231.
[1] Richardson SD, Plewa MJ, Wagner ED, et al. Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research[J]. Mutat Res,2007,636(1-3):178-242. [2] 中华人民共和国卫生部. GB5749-2006生活饮用水卫生标准[S].北京:中国标准出版社,2007. [3] 吴俊. 气相色谱法测定饮用水中二氯乙酸,三氯乙酸[J]. 中国卫生检验杂志,2013,(8):1893-1894. [4] 汪昆平,邓荣森,李伟民,等. 气相色谱-质谱法测定饮用水中的卤乙酸[J]. 色谱,2006,24(1):26-29. [5] 曾钰,陈军,王海瑞,等. 高效液相色谱法测定饮用水中的一氯乙酸和二氯乙酸[J]. 理化检验(化学分册),2014,(9):1173-1174. [6] 张伟林,王莹,魏慧珠. 离子色谱法测定水中消毒副产物的应用探讨[J]. 中国给水排水,2011,27(20):100-102. [7] 刘肖,史亚利,王碗,等. 离子色谱-串联电喷雾质谱法检测自来水中二氯乙酸和三氯乙酸[J]. 分析化学,2007,35(2):221-226. [8] Meng LP, Wu SM, Ma FJ, et al. Trace determination of nine haloacetic acids in drinking water by liquid chromatography-electrospray tandem mass spectrometry[J].J Chromatogr A,2010,1217(29):4873-4876. [9] Duan JM, Li W, S J, et al. Rapid determination of nine haloacetic acids in water using ultra-performance liquid chromatography- tandem mass spectrometry in multiple reactions.[J] Anal methods,2011,3:1667-1673. [10] 陈慧玲,刘红河,康莉,等. 液体奶及奶粉中黄曲霉毒素M1的液相色谱-串联质谱联用测定[J]. 实用预防医学,2014,21(6):742-745. [11] 张艳,陈剑刚,冯翠霞. 液相色谱-串联质谱法同时测定牛奶中7种雌激素类药物残留[J]. 实用预防医学,2013,20(6):740-743.
2016, Vol. 23 
