Abstract：Objective To explore umbilical cord blood procalcitonin (PCT) as a marker for early warning and diagnosis of neonatal intrauterine bacterial infection. Methods Newborns with high-risk factors of intrauterine infection and born in Hunan Provincial Maternal and Child Health Care Hospital during 2013-2015 were selected and divided into 4 groups according to the infection outcomes, including septicemia group, local infection group, non-infectious disease group and normal group. The levels of PCT and C reactive protein (CRP) in umbilical cord blood of the neonates of the 4 groups were detected. The distribution frequencies of different levels of the 2 inflammatory markers were compared among the 4 groups, and the sensitivities and specificities of the 2 inflammatory markers were analyzed. Results The levels of PCT and CRP in umbilical cord blood in the infected neonates were both increased. When PCT was 0.05-0.5 ng/ml, the distribution frequency of the non-infectious disease group was the highest (91.92%), and those of the local infection group and septicemia group were 40.32% and 30.91% respectively. Among the newborns hospitalized in the neonatal department, when 0.5 ng/ml was taken as the critical value of PCT, the sensitivity and specificity for the diagnosis of the infection were 59.75% and 93.94% respectively, of which those for the diagnoses of septicemia and local infection were 69.11% and 60.70%, 67.74% and 71.43% respectively. When 2.0 ng/ml was taken as the critical value of PCT, the sensitivity and specificity for the diagnosis of septicemia were 40.00% and 84.91% respectively. When 2 mg/L was taken as the critical value of CRP, the sensitivity and specificity for the diagnosis of the infection were 42.32% and 89.89% respectively, of which those for the diagnoses of septicemia and local infection were 47.27% and 69.82%, 40.86% and 70.17% respectively. Conclusions The sensitivity of 0.5 ng/ml umbilical cord blood PCT in the diagnosis of infection is higher than that of CRP, which can be used as a marker for early warning and auxiliary diagnosis of intrauterine bacterial infection. When PCT is above 2.0 ng/ml, the specificity for diagnosing septicemia reaches 84.91%. It is conducive to assessing different infection degrees and effectively guiding the clinical application of antibiotics and evaluation of curative effect.
刘赛红, 龚瑾, 刘志辉, 谭浩, 肖俏. 新生儿宫内细菌性感染中脐血降钙素原的早期预警和诊疗价值探讨[J]. 实用预防医学, 2016, 23(12): 1516-1518.
LIU Sai-hong, GONG Jin, LIU Zhi-hui, TAN Hao, XIAO Qiao. Early warning and diagnosis value of umbilical cord blood procalcitonin in neonatal intrauterine bacterial infection. , 2016, 23(12): 1516-1518.
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2016, Vol. 23 
